Strain Information | |
---|---|
Image | |
BRC No. | RBRC00379 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Hm+/+Reln<rl>/NemOdaRbrc |
Former Common name | C57BL/6-Hm/+-rl/+ |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Dr. Sen-ichi Oda, Nagoya University. This strain was generated by crossbreeding heterozygotic reeler (C57BL/6-rl) and hammer-toe (C57BL/6-Hm) mutants. |
Strain description | B6.Cg-Hm+/+Reln<rl>. This strain was generated by crossbreeding heterozygotic reeler (Reln<rl>) and hammer-toe (Hm) mutant mice to facilitate distinguishing between heterozygous reeler mice (rl/+) and wildtype. The Hammer-toe semidominant gene is located near reeler locus on the homologous chromosome. The reeler mutation causes an abnormal pattern in the layering of neurons in the neocortex and the cerebellum. The reeler homozygous (rl/rl) mutant mice show impaired motor coordination, tremors and ataxia. The hammer-toe homozygous (Hm/Hm) mutant mice show markedly-flexed digits having a fusion of the interdigital tissues, whereas in Hm heterozygotes (Hm/+) the degree of flexion is not so severe compared to those of homozygotes. |
Colony maintenance | Sibling mating (Hm +/+ rl x Hm +/+ rl)Reeler homozygous mutant mice show impaired motor coordination, tremors and ataxia, and die by 4 weeks of age. Hammer toe homozygous mutant mice are viable and fertile. |
References | Obstructed migration of Purkinje cells in the developing cerebellum of the reeler mutant mouse. Yuasa S, Kitoh J, Oda S, Kawamura K Anat. Embryol (Berl) 188, 317-329 (1993). 7506500名古屋大学環境医学研究所年報, 40, 266-267(1989). |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |||||||
---|---|---|---|---|---|---|---|
Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Hm | hammer toe | 5 | Hm | hammertoe | |||
Reln | reelin | 5 | Reln | reeler |
Phenotype | |
---|---|
Annotation by Mammalian phenotyhpe ontology | more 42 phenotypes |
Detailed phenotype data |
Ordering Information | |
---|---|
Donor DNA | |
Research application | |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. |
Depositor | Senichi Oda (Nagoya University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
---|
No Data |