Strain Data Sheet

RBRC00379

Strain Information

Image
BRC No.RBRC00379
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6.Cg-Hm+/+Reln<rl>/NemOdaRbrc
Former Common nameC57BL/6-Hm/+-rl/+
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Sen-ichi Oda, Nagoya University. This strain was generated by crossbreeding heterozygotic reeler (C57BL/6-rl) and hammer-toe (C57BL/6-Hm) mutants.
Strain descriptionB6.Cg-Hm+/+Reln<rl>. This strain was generated by crossbreeding heterozygotic reeler (Reln<rl>) and hammer-toe (Hm) mutant mice to facilitate distinguishing between heterozygous reeler mice (rl/+) and wildtype. The Hammer-toe semidominant gene is located near reeler locus on the homologous chromosome. The reeler mutation causes an abnormal pattern in the layering of neurons in the neocortex and the cerebellum. The reeler homozygous (rl/rl) mutant mice show impaired motor coordination, tremors and ataxia. The hammer-toe homozygous (Hm/Hm) mutant mice show markedly-flexed digits having a fusion of the interdigital tissues, whereas in Hm heterozygotes (Hm/+) the degree of flexion is not so severe compared to those of homozygotes.
Colony maintenanceSibling mating (Hm +/+ rl x Hm +/+ rl)Reeler homozygous mutant mice show impaired motor coordination, tremors and ataxia, and die by 4 weeks of age. Hammer toe homozygous mutant mice are viable and fertile.
References
Obstructed migration of Purkinje cells in the developing cerebellum of the reeler mutant mouse.
Yuasa S, Kitoh J, Oda S, Kawamura K
Anat. Embryol (Berl) 188, 317-329 (1993). 7506500

名古屋大学環境医学研究所年報, 40, 266-267(1989).

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Hmhammer toe5Hmhammertoe
  • epilepsy, familial temporal lobe, 1(MedGEN)

  • familial temporal lobe epilepsy 7(MedGEN)

  • Norman-Roberts syndrome(MedGEN)
  • Relnreelin5Relnreeler
  • epilepsy, familial temporal lobe, 1(MedGEN)

  • familial temporal lobe epilepsy 7(MedGEN)

  • Norman-Roberts syndrome(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • Purkinje cell degeneration(MP:0000876)

  • abnormal cerebellum morphology(MP:0000849)

  • abnormal cerebral cortex morphology(MP:0000788)

  • abnormal cortical marginal zone morphology(MP:0000792)

  • abnormal dentate gyrus morphology(MP:0000812)
  • more 42 phenotypes
  • abnormal entorhinal cortex morphology(MP:0006300)

  • abnormal female reproductive system physiology(MP:0003699)

  • abnormal gait(MP:0001406)

  • abnormal hippocampus CA1 region morphology(MP:0008263)

  • abnormal hippocampus CA2 region morphology(MP:0008265)

  • abnormal hippocampus morphology(MP:0000807)

  • abnormal hippocampus pyramidal cell layer(MP:0008284)

  • abnormal male reproductive system physiology(MP:0003698)

  • abnormal neuron differentiation(MP:0009937)

  • abnormal neuronal migration(MP:0006009)

  • abnormal olfactory cortex morphology(MP:0005267)

  • abnormal phalanx morphology(MP:0005306)

  • abnormal prepulse inhibition(MP:0003088)

  • abnormal sensory neuron innervation pattern(MP:0000968)

  • abnormal sexual interaction(MP:0002566)

  • abnormal short-term spatial reference memory(MP:0008431)

  • abnormal social investigation(MP:0001360)

  • abnormal stratification in cerebral cortex(MP:0000790)

  • abnormal ventral striatum morphology(MP:0004103)

  • ataxia(MP:0001393)

  • behavior/neurological phenotype(MP:0005386)

  • decreased Cajal-Retzius cell number(MP:0008031)

  • decreased Purkinje cell number(MP:0000880)

  • decreased body size(MP:0001265)

  • decreased body weight(MP:0001262)

  • decreased dopaminergic neuron number(MP:0011448)

  • decreased locomotor activity(MP:0001402)

  • diarrhea(MP:0005036)

  • disheveled coat(MP:0001511)

  • impaired balance(MP:0001525)

  • impaired righting response(MP:0001523)

  • infertility(MP:0001924)

  • interdigital webbing(MP:0000571)

  • lethality at weaning, complete penetrance(MP:0011083)

  • male infertility(MP:0001925)

  • nervous system phenotype(MP:0003631)

  • postnatal growth retardation(MP:0001732)

  • premature death(MP:0002083)

  • reduced female fertility(MP:0001923)

  • slow postnatal weight gain(MP:0008489)

  • small cerebellum(MP:0000852)

  • tremors(MP:0000745)
  • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorSenichi Oda (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data