Strain Data Sheet

RBRC00357

Strain Information

Image
BRC No.RBRC00357
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.Cg-Tnc<tm1Sia> Foxn1<nu>/Rbrc
Former Common nameBALB/cA-Tnc<tm1Sia>-nude; BALB/cA-TgH(Tnc)-Foxn1nu
H-2 Haplotype
ES Cell line
Background strainBALB/cA
Appearance
Strain developmentDeveloped by Dr. M. Kusakabe, Tsukuba Life Science Center, Institute of Physical and Chemical Research (RIKEN).
Strain descriptionC.Cg-Tnc<tm1Sia> Foxn1<nu>. Mice lacking tenascin C gene with a nude mutation. This strain is useful for studying the function of tenascin C in tumor proliferation and metastasis, neoangiogenesis, interoganizartional interation, and transplantation of human tumor.
Colony maintenance
References
Mice develop normally without tenascin.
Saga Y, Yagi T, Ikawa Y, Sakakura T, Aizawa S
Genes Dev., 6, 1821-1831 (1992). 1383086

Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse.
Koyama Y, Kusubata M, Yoshiki A, Hiraiwa N, Ohashi T, Irie S, Kusakabe M
J. Invest. Dermatol., 111, 930-935 (1998). 9856798

Tenascin-C promotes healing of Habu-snake venom-induced glomerulonephritis: studies in knockout congenic mice and in culture.
Nakao N, Hiraiwa N, Yoshiki A, Ike F, Kusakabe M
Am. J. Pathol., 152, 1237-1245 (1998). 9588892

Tyrosine hydroxylase activity and its mRNA level in dopaminergic neurons of tenascin gene knockout mouse.
Fukamauchi F, Mataga N, Wang Y J, Sato S, Yoshiki A, Kusakabe M
Biochem. Biophys. Res. Commun., 231, 356-359 (1997). 9070278

Abnormal behavior and neurotransmissions of tenascin gene knockout mouse.
Fukamauchi F, Mataga N, Wang Y J, Sato S, Youshiki A, Kusakabe M
Biochem. Biophys. Res. Commun., 221, 151-156 (1996). 8660327

PDGF receptor-alpha deficiency in glomerular mesangial cells of tenascin-C knockout mice.
Matsumoto K, Hiraiwa N, Yoshiki A, Ohnishi M, Kusakabe M
Biochem. Biophys. Res. Commun., 290, 1220-1227 (2002). 11811993

Corneal wound healing in tenascin knockout mouse.
Matsuda A, Yoshiki A, Tagawa Y, Matsuda H, Kusakabe M
Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999). 10235540

Loss of cortical and thalamic neuronal tenascin-C expression in a transgenic mouse expressing exon 1 of the human Huntington disease gene.
Kusakabe M, Mangiarini L, Laywell E D, Bates G P, Yoshiki A, Hiraiwa N, Inoue J, Steindler D A
J. Comp. Neurol., 430, 485-500 (2001). 11169482

Murine tenascin: cDNA cloning, structure and temporal expression of isoforms.
Saga Y, Tsukamoto T, Jing N, Kusakabe M, Sakakura T
Gene, 104, 177-185 (1991). 1717349

Tenascin knockout mice: barrels, boundary molecules, and glial scars.
Steindler D A, Settles D, Erickson H P, Laywell E D, Yoshiki A, Faissner A, Kusakabe M
J. Neurosci., 15, 1971-1983 (1995). 7534342
more 5 references
Tenascin-C expression and splice variant in habu snake venom-induced glomerulonephritis.
Matsumoto K, Hiraiwa N, Yoshiki A, Ohnishi M, Kusakabe M
Exp. Mol. Pathol., 72, 186-195 (2002). 12009782

22nd Congress of the International Association for Breast Cancer Research Athens, Greece 25-28 September, pp 197-201 (1998). 9863494

乳癌基礎研究, 8, 26-31 (1999).

乳癌基礎研究, 5, 41-45 (1996).

炎症, 15(5), 377-381 (1996).

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Foxn1forkhead box N111Foxn1nude
  • autosomal dominant nonsyndromic hearing loss 56(MedGEN)

  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy(DisGeNET, MedGEN)

  • T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant(MedGEN)
    • Tnctenascin C4Tnctargeted mutation 1, Shinichi Aizawa
  • autosomal dominant nonsyndromic hearing loss 56(MedGEN)

  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy(DisGeNET, MedGEN)

  • T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant(MedGEN)
    • lacZbeta-galactosidase (E. coli)4
  • autosomal dominant nonsyndromic hearing loss 56(MedGEN)

  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy(DisGeNET, MedGEN)

  • T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant(MedGEN)
    • neoneomycin resistance gene (E. coli)4mouse phosphoglycerate kinase promoter (PGK promoter)
  • autosomal dominant nonsyndromic hearing loss 56(MedGEN)

  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy(DisGeNET, MedGEN)

  • T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal CNS synaptic transmission(MP:0002206)

  • abnormal Peyer's patch germinal center morphology(MP:0002391)

  • abnormal Peyer's patch morphology(MP:0000696)

  • abnormal T cell activation(MP:0001828)

  • abnormal T cell physiology(MP:0002444)
    • more 100 phenotypes
  • abnormal circadian behavior(MP:0020467)

  • abnormal circulating cytokine level(MP:0010210)

  • abnormal circulating gonadotropin level(MP:0003361)

  • abnormal coat/ hair morphology(MP:0000367)

  • abnormal compact bone morphology(MP:0003797)

  • abnormal corneocyte morphology(MP:0030605)

  • abnormal cutaneous collagen fibril morphology(MP:0008438)

  • abnormal embryonic tissue morphology(MP:0002085)

  • abnormal epidermal layer morphology(MP:0001216)

  • abnormal epidermis stratum basale morphology(MP:0001231)

  • abnormal epidermis stratum corneum morphology(MP:0001240)

  • abnormal epidermis stratum granulosum morphology(MP:0001239)

  • abnormal estrous cycle(MP:0001927)

  • abnormal hair cortex keratinization(MP:0009801)

  • abnormal hair cortex morphology(MP:0003811)

  • abnormal hair cuticle(MP:0003810)

  • abnormal hair follicle inner root sheath morphology(MP:0010685)

  • abnormal hair follicle morphology(MP:0000377)

  • abnormal hair shaft morphology(MP:0003809)

  • abnormal liver morphology(MP:0000598)

  • abnormal lymph node T cell domain morphology(MP:0002347)

  • abnormal lymph node morphology(MP:0002339)

  • abnormal muscle morphology(MP:0002108)

  • abnormal nail matrix morphology(MP:0012405)

  • abnormal nail morphology(MP:0000579)

  • abnormal nail plate morphology(MP:0012403)

  • abnormal response/metabolism to endogenous compounds(MP:0003638)

  • abnormal serotonin level(MP:0005322)

  • abnormal spleen morphology(MP:0000689)

  • abnormal spleen physiology(MP:0008737)

  • abnormal splenic cell ratio(MP:0008826)

  • abnormal thymus development(MP:0000704)

  • abnormal thymus epithelium morphology(MP:0009544)

  • abnormal thymus morphology(MP:0000703)

  • abnormal trabecular bone morphology(MP:0000130)

  • abnormal venule morphology(MP:0004125)

  • absent B cells(MP:0008071)

  • absent Peyer's patches(MP:0002831)

  • absent lymph nodes(MP:0008024)

  • absent spleen(MP:0000690)

  • absent vibrissae(MP:0001284)

  • ascites(MP:0005324)

  • asthenozoospermia(MP:0002675)

  • athymia(MP:0000705)

  • blepharitis(MP:0005251)

  • chromosomal instability(MP:0008866)

  • coiled sperm flagellum(MP:0009238)

  • decreased T cell number(MP:0005018)

  • decreased body size(MP:0001265)

  • decreased body weight(MP:0001262)

  • decreased circulating alanine transaminase level(MP:0002942)

  • decreased circulating follicle stimulating hormone level(MP:0002790)

  • decreased circulating interleukin-2 level(MP:0008600)

  • decreased circulating interleukin-6 level(MP:0008597)

  • decreased circulating luteinizing hormone level(MP:0002773)

  • decreased circulating tumor necrosis factor level(MP:0008554)

  • decreased dopamine level(MP:0005643)

  • decreased gamma-delta intraepithelial T cell number(MP:0008351)

  • decreased inflammatory response(MP:0001876)

  • decreased interferon-gamma secretion(MP:0008567)

  • decreased leukocyte cell number(MP:0000221)

  • decreased lymphocyte cell number(MP:0005016)

  • decreased metastatic potential(MP:0001273)

  • decreased skeletal muscle fiber size(MP:0009400)

  • decreased skeletal muscle mass(MP:0004819)

  • decreased susceptibility to bacterial infection(MP:0002411)

  • decreased susceptibility to parasitic infection(MP:0005026)

  • decreased susceptibility to viral infection(MP:0002410)

  • decreased thymocyte number(MP:0000715)

  • decreased tumor incidence(MP:0002052)

  • deformed nails(MP:0000580)

  • female infertility(MP:0001926)

  • hairless(MP:0003815)

  • hyperactivity(MP:0001399)

  • impaired spatial learning(MP:0012307)

  • impaired swimming(MP:0001522)

  • increased IgA level(MP:0002495)

  • increased bone mineral density(MP:0000062)

  • increased erythroid progenitor cell number(MP:0003135)

  • increased length of allograft survival(MP:0004751)

  • increased plasmacytoma incidence(MP:0010286)

  • increased stereotypic behavior(MP:0001409)

  • increased susceptibility to viral infection induced morbidity/mortality(MP:0009791)

  • increased susceptibility to viral infection(MP:0002418)

  • increased thymocyte apoptosis(MP:0009541)

  • infertility(MP:0001924)

  • nail dystrophy(MP:0012400)

  • no abnormal phenotype detected(MP:0002169)

  • postnatal growth retardation(MP:0001732)

  • postnatal lethality, incomplete penetrance(MP:0011086)

  • premature death(MP:0002083)

  • reduced hair shaft melanin granule number(MP:0008732)

  • reduced male fertility(MP:0001922)

  • short nails(MP:0012399)

  • short vibrissae(MP:0001282)

  • small ovary(MP:0001127)

  • small spleen(MP:0000692)

  • thin skin(MP:0001199)

  • thrombocytosis(MP:0005505)

  • wavy vibrissae(MP:0001279)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse tenascin genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Am. J. Pathol., 152, 1237-1245 (1998). J. Invest. Dermatol., 111, 930-935 (1998). Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999).
    DepositorRIKEN BRC (RIKEN BRC)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data