Strain Data Sheet

RBRC00324

Strain Information

Image
BRC No.RBRC00324
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6CBA-A<w-J>/A-Lc/+ (small eye)
Former Common nameB6CBA-AW-J/A-Lc/+-eyeless, lurcher eyeless
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description小眼高発系統．小眼症の程度は左右非対称のケースが多い．成体の多くは眼瞼は開いているが，中には著しい小眼球で眼瞼が閉鎖したままの個体もいる．眼瞼の開いた個体では多くの場合，角膜は透明で水晶体白濁しており，虹彩内の小白点として認められる．角膜の肥厚と懸濁を伴う眼球をもつ個体もいる．F17世代で出現
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Grid2
MGI:95813		glutamate receptor, ionotropic, delta 26Grid2<Lc>
MGI:1857337		lurcher
  • autosomal recessive spinocerebellar ataxia 18(DisGeNET, MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal cornea thickness (MP:0011961)

  • abnormal hair follicle melanogenesis (MP:0004382)

  • abnormal ventral coat pigmentation (MP:0008237)

  • blepharoptosis (MP:0001344)

  • cataract (MP:0001304)
    • more 3 phenotypes
  • cornea opacity (MP:0001314)

  • decreased circulating pituitary hormone level (MP:0005118)

  • microphthalmia (MP:0001297)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationSensorineural Research
    提供条件条件を付加しない。
    DepositorRIKEN BRC（独立行政法人理化学研究所）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data