Strain Data Sheet

RBRC00319

Strain Information

Image
BRC No.RBRC00319
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameK15
Former Common nameTg.Tlaa-3-2, K15
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Expression of TL, H-2, and chimeric H-2/TL genes in transgenic mice: abnormal thymic differentiation and T-cell lymphomas in a TL transgenic strain.
Hamasima N, Takahashi T, Taguchi O, Nishizuka Y, Stockert E, Old L J, Obata Y
Proc. Natl. Acad. Sci. USA, 86, 7995-7999 (1989). 2813374

Abnormal thymic development, impaired immune function and gamma delta T cell lymphomas in a TL transgenic mouse strain.
Obata Y, Taguchi O, Matsudaira Y, Hasegawa H, Hamasima N, Takahashi T
J. Exp. Med., 174, 351-362 (1991). 1713249

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal T cell differentiation(MP:0002145)

  • abnormal T cell physiology(MP:0002444)

  • abnormal lymph node cell ratio(MP:0008828)

  • abnormal lymph node size(MP:0000701)

  • abnormal spleen size(MP:0002224)
  • more 11 phenotypes
  • abnormal thymus development(MP:0000704)

  • abnormal thymus morphology(MP:0000703)

  • abnormal thymus size(MP:0002364)

  • abnormal thymus weight(MP:0004954)

  • decreased spleen weight(MP:0004953)

  • decreased splenocyte number(MP:0009339)

  • decreased thymus weight(MP:0004956)

  • increased T cell acute lymphoblastic leukemia incidence(MP:0014049)

  • small lymph nodes(MP:0002217)

  • small spleen(MP:0000692)

  • small thymus(MP:0000706)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse (A strain thymocyes) Tlaa-3 genomic DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorToshitada Takahashi (Aichi Cancer Center)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data