Strain Data Sheet

RBRC00312

Strain Information

Image
BRC No.RBRC00312
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameK4
Former Common nameTg.Tlaa-3-1, K4
H-2 Haplotype
ES Cell line
Background strainC3H/HeNCrlCrlj
Appearance
Strain development
Strain description
Colony maintenance
References
Expression of TL, H-2, and chimeric H-2/TL genes in transgenic mice: abnormal thymic differentiation and T-cell lymphomas in a TL transgenic strain.
N Hamasima, T Takahashi, O Taguchi, Y Nishizuka, E Stockert, L J Old, Y Obata
Proc. Natl. Acad. Sci. USA, 86, 7995-7999 (1989). 2813374

Abnormal thymic development, impaired immune function and gamma delta T cell lymphomas in a TL transgenic mouse strain.
Y Obata, O Taguchi, Y Matsudaira, H Hasegawa, N Hamasima, T Takahashi
J. Exp. Med., 174, 351-362 (1991). 1713249

Genetics in Wild Mice, 159-177 (1994). ISBN4762277746

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tlaa-3 TL antigen a-3UNTlaa-3

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal T cell differentiation (MP:0002145)

  • abnormal T cell number (MP:0006387)

  • abnormal T cell receptor gamma chain V-J recombination (MP:0008757)

  • decreased CD4-positive, alpha-beta T cell number (MP:0008075)

  • decreased CD8-positive, alpha-beta T cell number (MP:0008079)
    • more 4 phenotypes
  • decreased T cell number (MP:0005018)

  • increased T cell acute lymphoblastic leukemia incidence (MP:0014049)

  • lymph node inflammation (MP:0003865)

  • small thymus (MP:0000706)
    • Detailed phenotype data

    Ordering Information

    供与核酸mouse (A strain thymocyes) Tlaa-3 genomic DNA
    Research application
    提供条件条件を付加しない。
    Depositor高橋　利忠（愛知県がんセンター）
    Strain Status凍結精子のアイコン凍結精子
    Strain Availability凍結精子より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data