Strain Data Sheet

RBRC00312

Strain Information

Image
BRC No.RBRC00312
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameK4
Former Common nameTg.Tlaa-3-1, K4
H-2 Haplotype
ES Cell line
Background strainC3H/HeNCrlCrlj
Appearance
Strain development
Strain description
Colony maintenance
References
Expression of TL, H-2, and chimeric H-2/TL genes in transgenic mice: abnormal thymic differentiation and T-cell lymphomas in a TL transgenic strain.
Hamasima N, Takahashi T, Taguchi O, Nishizuka Y, Stockert E, Old L J, Obata Y
Proc. Natl. Acad. Sci. USA, 86, 7995-7999 (1989). 2813374

Abnormal thymic development, impaired immune function and gamma delta T cell lymphomas in a TL transgenic mouse strain.
Obata Y, Taguchi O, Matsudaira Y, Hasegawa H, Hamasima N, Takahashi T
J. Exp. Med., 174, 351-362 (1991). 1713249

Genetics in Wild Mice, 159-177 (1994). ISBN4762277746

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tlaa-3TL antigen a-3UNTlaa-3

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal T cell differentiation(MP:0002145)

  • abnormal T cell number(MP:0006387)

  • abnormal T cell receptor gamma chain V-J recombination(MP:0008757)

  • decreased CD4-positive, alpha-beta T cell number(MP:0008075)

  • decreased CD8-positive, alpha-beta T cell number(MP:0008079)
  • more 4 phenotypes
  • decreased T cell number(MP:0005018)

  • increased T cell acute lymphoblastic leukemia incidence(MP:0014049)

  • lymph node inflammation(MP:0003865)

  • small thymus(MP:0000706)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse (A strain thymocyes) Tlaa-3 genomic DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorToshitada Takahashi (Aichi Cancer Center)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data