Strain Information | |
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Image | |
BRC No. | RBRC00237 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6.129X1-Achrg<tm1Mtak>/40Rbrc |
Former Common name | C57BL/6-TgH(AchR-gamma/40) |
H-2 Haplotype | |
ES Cell line | RW4 [129X1/SvJ] |
Background strain | C57BL/6JJcl |
Appearance | black |
Strain development | |
Strain description | |
Colony maintenance | |
References | Spontaneous muscle action potentials fail to develop without fetal-type acetylcholine receptors. Takahashi M, Kubo T, Mizoguchi A, Carlson C G, Endo K, Ohnishi K EMBO Rep., 3, 674-681 (2002). 12101101Deficient development and maintenance of postsynaptic specializations in mutant mice lacking an 'adult' acetylcholine receptor subunit. Missias A C, Mudd J, Cunningham J M, Steinbach J H, Merlie J P, Sanes J R Development, 124, 5075-5086 (1997). 9362465Acetylcholine receptor epsilon-subunit deletion causes muscle weakness and atrophy in juvenile and adult mice. Witzemann V, Schwarz H, Koenen M, Berberich C, Villarroel A, Wernig A, Brenner H R, Sakmann B Proc. Natl. Acad. Sci. USA, 93, 13286-13291 (1996). 8917583Differential regulation of muscle acetylcholine receptor gamma- and epsilon-subunit mRNAs. Witzemann V, Barg B, Nishikawa Y, Sakmann B, Numa S FEBS Lett., 223, 104-112 (1987). 3666131Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death. Bruschi S A, Lindsay J G, Crabb J W Proc. Natl. Acad. Sci. USA, 95, 13413-13418 (1998). 9811814 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Chrng | cholinergic receptor, nicotinic, gamma polypeptide | 1 | Chrng | targeted mutation 1, Masazumi Takahashi | |||
neo | neomycin resistance gene (E. coli) | 1 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 8 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse muscle type nicotinic acetylcholine receptor gamma subunit |
Research application | Neurobiology Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Masazumi Takahashi (Centre National de Genotypage) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |