Strain Data Sheet

RBRC00224

Strain Information

Image
BRC No.RBRC00224
TypeInbred
SpeciesMus musculus
Strain nameSL/Ni
Former Common name
H-2 Haplotypeq
ES Cell line
Background strainSL/NiStm
Appearancealbino
Strain developmentThis strain originated from outbred Swiss mice, and the four substrains of SL family had been established at Kyushyu University. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute.Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by Caesarean section, and introduced into the SPF facility. The mice are maintained by sister-brother mating. Females and males in the same litter are recommended to mate just after weaning. When females and males from the different litters are used, males of 8-12 weeks old and females of 4-8 weeks old breed well.
Strain descriptionThis strain has been established in Japan. Outbred Swiss mouse origin. High incidence of lymphoma was found in SL/Am, and not in SL/Ni.There are four substrains of SL family, DL/QDj, SL/Am, SL/Ni and SL/Kh. The SL/Ni and SL/Am strains are almost identical and share similar genetic background with the proto-SL strain.
Colony maintenance
References
Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice.
Lu L M, Shimada R, Higashi S, Zeng Z, Hiai H
Cancer Res., 59, 2593-2595 (1999). 10363979

Genetic predisposition to pre-B lymphomas in SL/Kh strain mice.
Yamada Y, Matsushiro H, Ogawa M S, Okamoto K, Nakakuki Y, Toyokuni S, Fukumoto M, Hiai H
Cancer Res., 54, 403-407 (1994). 8275476

Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
Okamoto K, Yamada Y, Ogawa M S, Toyokuni S, Nakakuki Y, Ikeda H, Yoshida O, Hiai H
Cancer Res., 54, 399-402 (1994). 8275475

Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.
Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H
Proc. Natl. Acad. Sci. USA, 99, 8253-8258 (2002). 12048235

Epigenetic control of endogenous ecotropic virus expression in SL/Ni mice.
Hiai H, Buma Y O, Ikeda H, Moriwaki K, Nishizuka Y
J. Natl. Cancer Inst., 79, 781-787 (1987). 3477660

The origin of SL family mice.
Abujiang P, Yamada Y, Haller O, Kobayashi H, Kamoto T, Lu L M, Ogawa M, Ishimoto A, Katoh H, Kanehira K, Ikegami S, Fukumoto M, Hiai H
Lab. Anim. Sci., 46, 410-417 (1996). 8872992

T lymphomagenesis is determined by a dominant host gene thymic lymphoma susceptible mouse-1 (TLSM-1) in mouse models.
Yamada Y, Shisa H, Matsushiro H, Kamoto T, Kobayashi Y, Kawarai A, Hiai H
J. Exp. Med., 180, 2155-2162 (1994). 7964490

Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms.
Pataer A, Kamoto T, Lu L M, Yamada Y, Hiai H
Cancer Res., 56, 3716-3720 (1996). 8706013

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal pre-B cell morphology(MP:0002403)

  • increased B cell derived lymphoma incidence(MP:0002023)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationCancer Research
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorHayase Shisa (Saitama Cancer Center)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data