Strain Data Sheet

RBRC00222

Strain Information

Image
BRC No.RBRC00222
TypeInbred
SpeciesMus musculus
Strain nameSL/Kh
Former Common name
H-2 Haplotype
ES Cell line
Background strainSL/KhStm
Appearancealbino [A/A, B/B, c/c]
Strain developmentSL系統はSwiss miceの交雑群に由来し，白血病高発系統として遺伝研の土川博士によって育成された．その後，九大で4つにサブライン化された．SL/Khはそのうちの一つ．その後，愛知県がんセンターを経て(+F35)，埼玉がんセンター(志佐博士)へ導入されたのち(+F54-55)，理研BRCへ導入された．白血病高発系統．連産性は低い．3カ月程度で精子が採取できなくなる．飼育過密が高いと癌を高発する傾向がある。
Strain descriptionSL/Khは内在性レトロウィルスのプロウィルスの挿入による遺伝子の活性化によりリンパ腫を発生する．SL/Khの一部のリンパ腫はプロウィルスによりStat5aがさまざまな遺伝子を活性化し，かつ多くの因子と対応することによって，Pro-B細胞の腫瘍増殖によるものであることが明らかになっている．B細胞の初期分化過程とそのガン化を研究する上で有用なモデルマウスである．
Colony maintenanceSibling Mating
References
Epigenetic control of endogenous ecotropic virus expression in SL/Ni mice.
H Hiai, Y O Buma, H Ikeda, K Moriwaki, Y Nishizuka
J. Natl. Cancer Inst., 79, 781-787 (1987). 3477660

Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
K Okamoto, Y Yamada, M S Ogawa, S Toyokuni, Y Nakakuki, H Ikeda, O Yoshida, H Hiai
Cancer Res., 54, 399-402 (1994). 8275475

Genetic predisposition to pre-B lymphomas in SL/Kh strain mice.
Y Yamada, H Matsushiro, M S Ogawa, K Okamoto, Y Nakakuki, S Toyokuni, M Fukumoto, H Hiai
Cancer Res., 54, 403-407 (1994). 8275476

T lymphomagenesis is determined by a dominant host gene thymic lymphoma susceptible mouse-1 (TLSM-1) in mouse models.
Y Yamada, H Shisa, H Matsushiro, T Kamoto, Y Kobayashi, A Kawarai, H Hiai
J. Exp. Med., 180, 2155-2162 (1994). 7964490

The origin of SL family mice.
P Abujiang, Y Yamada, O Haller, H Kobayashi, T Kamoto, L M Lu, M Ogawa, A Ishimoto, H Katoh, K Kanehira, S Ikegami, M Fukumoto, H Hiai
Lab. Anim. Sci., 46, 410-417 (1996). 8872992

Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms.
A Pataer, T Kamoto, L M Lu, Y Yamada, H Hiai
Cancer Res., 56, 3716-3720 (1996). 8706013

Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice.
L M Lu, R Shimada, S Higashi, Z Zeng, H Hiai
Cancer Res., 59, 2593-2595 (1999). 10363979

Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.
Tatsuaki Tsuruyama, Takuro Nakamura, Guang Jin, Munetaka Ozeki, Yoshihiro Yamada, Hiroshi Hiai
Proc. Natl. Acad. Sci. USA, 99, 8253-8258 (2002). 12048235

Health Report

Examination Date / Room / Rack2025/09/01Room:3-BRack:L囮検査
2025/06/16Room:3-BRack:L囮検査
2025/04/07Room:3-BRack:L囮検査
2025/01/07Room:3-BRack:L囮検査
2024/10/07Room:3-BRack:L囮検査
2024/07/08Room:3-BRack:L囮検査

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Bomb1
MGI:1332642		bone marrow pre-B 13Bomb1<SL/Kh>
MGI:2155342
Tlsm1
MGI:105954		thymic lymphoma susceptible 17Tlsm1<SL/Kh>
MGI:2156831		thymic lymphoma susceptible 1; SL/Kh

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • increased T cell derived lymphoma incidence (MP:0002024)

  • increased lymphoma incidence (MP:0012431)

  • increased pre-B cell number (MP:0003132)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationCancer Research
    提供条件条件を付加しない。
    Depositor志佐　湍（埼玉県立がんセンター研究所）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Tatsuaki Tsuruyama.
    DNA insertion mutations can be predicted by a periodic probability function.
    arXiv (2017)
    Tsuruyama T, Hiratsuka T, Aini W, Nakamura T.
    STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner.
    J Cell Biochem 117(11) 2630-42(2016) 27018255
    Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T.
    ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.
    Oncogene 35(25) 3227-38(2016) 26522721
    Tsuruyama T, Liu W, Yoshikawa K.
    In vitro murine leukemia retroviral integration and structure fluctuation of target DNA.
    PLoS One 7(2) e31533(2012) 22348097
    Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H.
    Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis.
    Leuk Res 32(2) 309-14(2008) 17617450
    Hiai H.
    Genetic and virological predisposition to pre-B lymphomagenesis in SL/Kh. In: Mouse Models of Human Blood Cancers: Basic Research and Pre-Clinical Applications, ed. Li, S.
    Springer-Verlag 227-244(2008)
    Jin G, Tsuruyama T, Yamada Y, Hiai H.
    Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas.
    Cancer Sci 94(9) 791-5(2003) 12967477
    Hiai H, Tsuruyama T, Yamada Y.
    Pre-B lymphomas in SL/Kh mice: a multifactorial disease model.
    Cancer Sci 94(10) 847-50(2003) 14556656
    Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC 3rd, Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium.
    Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
    Blood 100(1) 238-45(2002) 12070033
    Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H.
    Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.
    Proc Natl Acad Sci U S A 99(12) 8253-8(2002) 12048235