Strain Data Sheet

RBRC00222

update : 2024-04-19

Strain Information
Image
BRC No.	RBRC00222
Type	Inbred
Species	Mus musculus
Strain name	SL/Kh
Former Common name
H-2 Haplotype
ES Cell line
Background strain	SL/KhStm
Appearance	albino [A/A, B/B, c/c]
Strain development	SL系統はSwiss miceの交雑群に由来し，白血病高発系統として遺伝研の土川博士によって育成された．その後，九大で4つにサブライン化された．SL/Khはそのうちの一つ．その後，愛知県がんセンターを経て(+F35)，埼玉がんセンター(志佐博士)へ導入されたのち(+F54-55)，理研BRCへ導入された．白血病高発系統．連産性は低い．3カ月程度で精子が採取できなくなる．飼育過密が高いと癌を高発する傾向がある。
Strain description	SL/Khは内在性レトロウィルスのプロウィルスの挿入による遺伝子の活性化によりリンパ腫を発生する．SL/Khの一部のリンパ腫はプロウィルスによりStat5aがさまざまな遺伝子を活性化し，かつ多くの因子と対応することによって，Pro-B細胞の腫瘍増殖によるものであることが明らかになっている．B細胞の初期分化過程とそのガン化を研究する上で有用なモデルマウスである．
Colony maintenance	Sibling Mating
References	J. Exp. Med., 180, 2155-2162 (1994). 7964490 J. Natl. Cancer Inst., 79, 781-787 (1987). 3477660 Cancer Res., 54, 399-402 (1994). 8275475 Proc. Natl. Acad. Sci. USA, 99, 8253-8258 (2002). 12048235 Lab. Anim. Sci., 46, 410-417 (1996). 8872992 Cancer Res., 59, 2593-2595 (1999). 10363979 Cancer Res., 54, 403-407 (1994). 8275476 Cancer Res., 56, 3716-3720 (1996). 8706013

Health Report
Examination Date / Room / Rack

Gene
Gene info	Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Bomb1bone marrow pre-B 13Bomb1<SL/Kh> Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Tlsm1thymic lymphoma susceptible 17Tlsm1<SL/Kh>thymic lymphoma susceptible 1; SL/Kh

Ordering Information
供与核酸
Research application	Cancer Research
提供条件	条件を付加しない。
Depositor	志佐　湍（埼玉県立がんセンター研究所）
Strain Status	凍結胚
Strain Availability	凍結胚より作出したマウスを2~4ヶ月以内に提供可能凍結胚を1ヶ月以内に提供可能
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Genotyping protocol -PCR-

BRC mice in Publications

Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC 3rd, Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood 100(1) 238-45(2002) 12070033 Jin G, Tsuruyama T, Yamada Y, Hiai H. Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas. Cancer Sci 94(9) 791-5(2003) 12967477 Hiai H, Tsuruyama T, Yamada Y. Pre-B lymphomas in SL/Kh mice: a multifactorial disease model. Cancer Sci 94(10) 847-50(2003) 14556656 Tsuruyama T, Hiratsuka T, Aini W, Nakamura T. STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner. J Cell Biochem 117(11) 2630-42(2016) 27018255 Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H. Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis. Leuk Res 32(2) 309-14(2008) 17617450 Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T. ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway. Oncogene 35(25) 3227-38(2016) 26522721 Tsuruyama T, Liu W, Yoshikawa K. In vitro murine leukemia retroviral integration and structure fluctuation of target DNA. PLoS One 7(2) e31533(2012) 22348097 Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H. Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. Proc Natl Acad Sci U S A 99(12) 8253-8(2002) 12048235 Hiai H. Genetic and virological predisposition to pre-B lymphomagenesis in SL/Kh. In: Mouse Models of Human Blood Cancers: Basic Research and Pre-Clinical Applications, ed. Li, S. Springer-Verlag 227-244(2008) Tatsuaki Tsuruyama. DNA insertion mutations can be predicted by a periodic probability function. arXiv (2017)

BRC mice in Publications

Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC 3rd, Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium.
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
Blood 100(1) 238-45(2002) 12070033

Jin G, Tsuruyama T, Yamada Y, Hiai H.
Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas.
Cancer Sci 94(9) 791-5(2003) 12967477

Hiai H, Tsuruyama T, Yamada Y.
Pre-B lymphomas in SL/Kh mice: a multifactorial disease model.
Cancer Sci 94(10) 847-50(2003) 14556656

Tsuruyama T, Hiratsuka T, Aini W, Nakamura T.
STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner.
J Cell Biochem 117(11) 2630-42(2016) 27018255

Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H.
Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis.
Leuk Res 32(2) 309-14(2008) 17617450

Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T.
ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.
Oncogene 35(25) 3227-38(2016) 26522721

Tsuruyama T, Liu W, Yoshikawa K.
In vitro murine leukemia retroviral integration and structure fluctuation of target DNA.
PLoS One 7(2) e31533(2012) 22348097

Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H.
Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.
Proc Natl Acad Sci U S A 99(12) 8253-8(2002) 12048235

Hiai H.
Genetic and virological predisposition to pre-B lymphomagenesis in SL/Kh. In: Mouse Models of Human Blood Cancers: Basic Research and Pre-Clinical Applications, ed. Li, S.
Springer-Verlag 227-244(2008)

Tatsuaki Tsuruyama.
DNA insertion mutations can be predicted by a periodic probability function.
arXiv (2017)

Strain Information

Health Report

Gene

Ordering Information

BRC mice in Publications