Strain Data Sheet


Strain Information

BRC No.RBRC00222
SpeciesMus musculus
Strain nameSL/Kh
Former Common name
H-2 Haplotype
ES Cell line
Background strainSL/KhStm
Appearancealbino [A/A, B/B, c/c]
Strain developmentThe spontaneous leukemia (SL) strain was originated from outbred Swiss albino mice, developed as a high-leukemia strain by Dr. K. Tsuchikawa in Mishima. At least 4 substrains, namely SL/Am, SL/Kh, SL/Ni, and SL/QDj had been established and maintained. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute. Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by caesarean section, and introduced into the SPF facility.High incidence of pre-B lymphomas at early age
Strain descriptionSL/Kh is a member of the spontaneous leukemia family of mice, originated from outbred Swiss albino mice. Based on genotype analysis using microsatellite markers, SL/Kh was defined as a recombinant congenic strain between proto-SL and AKR strain mice. This strain develops pre-B lympomas by reintegration of the endogenous ecotropic MuLV provirus into a number of common integration sites, including Stat5a, Evi3, c-Myc, Stat5b, N-Myc, and others. SL/Kh is useful for an excellent multifactorial disease model.
Colony maintenanceSibling Mating
ReferencesJ. Natl. Cancer Inst., 79, 781-787 (1987). 3477660
Lab. Anim. Sci., 46, 410-417 (1996). 8872992
Proc. Natl. Acad. Sci. USA, 99, 8253-8258 (2002). 12048235
Cancer Res., 59, 2593-2595 (1999). 10363979
Cancer Res., 54, 403-407 (1994). 8275476
J. Exp. Med., 180, 2155-2162 (1994). 7964490
Cancer Res., 56, 3716-3720 (1996). 8706013
Cancer Res., 54, 399-402 (1994). 8275475

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Bomb1bone marrow pre-B 13Bomb1<SL/Kh>

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Tlsm1thymic lymphoma susceptible 17Tlsm1<SL/Kh>thymic lymphoma susceptible 1; SL/Kh

Ordering Information

Donor DNA
Research applicationCancer Research
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorHayase Shisa (Saitama Cancer Center)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC 3rd, Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium.
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
Blood 100(1) 238-45(2002) 12070033

Jin G, Tsuruyama T, Yamada Y, Hiai H.
Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas.
Cancer Sci 94(9) 791-5(2003) 12967477

Hiai H, Tsuruyama T, Yamada Y.
Pre-B lymphomas in SL/Kh mice: a multifactorial disease model.
Cancer Sci 94(10) 847-50(2003) 14556656

Tsuruyama T, Hiratsuka T, Aini W, Nakamura T.
STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner.
J Cell Biochem 117(11) 2630-42(2016) 27018255

Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H.
Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis.
Leuk Res 32(2) 309-14(2008) 17617450

Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T.
ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.
Oncogene 35(25) 3227-38(2016) 26522721

Tsuruyama T, Liu W, Yoshikawa K.
In vitro murine leukemia retroviral integration and structure fluctuation of target DNA.
PLoS One 7(2) e31533(2012) 22348097

Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H.
Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.
Proc Natl Acad Sci U S A 99(12) 8253-8(2002) 12048235

Hiai H.
Genetic and virological predisposition to pre-B lymphomagenesis in SL/Kh. In: Mouse Models of Human Blood Cancers: Basic Research and Pre-Clinical Applications, ed. Li, S.
Springer-Verlag 227-244(2008)

Tatsuaki Tsuruyama.
DNA insertion mutations can be predicted by a periodic probability function.
arXiv (2017)