Strain Information | |
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Image | |
BRC No. | RBRC00209 |
Type | Wild-derived Inbred |
Species | Mus musculus molossinus |
Strain name | MSM/Ms |
Former Common name | M.MOL-MSM |
H-2 Haplotype | |
ES Cell line | |
Background strain | MSM [Mus musculus molossinus] |
Appearance | white-bellied agouti [Aw/Aw] |
Strain development | Developed by National Institute of Genetics. Sibling x Sibling. Productive mating: 60.6% (n=53); First mating: 77.7 days (n=14); Litter size: 5.2 pups (n=102) |
Strain description | Wild-derived inbred strain of Mus musculus molossinus, collected at Mishima, Shizuoka, Japan in April 1978 and maintained by Kazuo Mrowaki, National Institute of Genetics. This strain has been reported to be resistant to the development of lymphoma and obesity. MSM can be used to support research in many areas including cancer and genetics. |
Colony maintenance | |
References | Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes. Masui T, Tezuka N, Nakanishi H, Inada K, Miyashita N, Tatematsu M Cancer Lett., 111, 97-104 (1997). 9022133Novel mutation of topoisomerase I in rendering cells resistant to camptothecin. Chang J Y, Liu J F, Juang S H, Liu T W, Chen L T Cancer Res., 56, 3716-3720 (1996). 12097280Radiation-induced lymphomas in MSM, (BALB/cHeA x MSM) F1 and (BALB/cHeA x STS/A) F1 hybrid mice. Okumoto M, Mori N, Miyashita N, Moriwaki K, Imai S, Haga S, Hiroishi S, Takamori Y, Esaki K Exp. Anim., 44, 43-48 (1995). 7705478Contribution of Asian mouse subspecies Mus musculus molossinus to genomic constitution of strain C57BL/6J, as defined by BAC-end sequence-SNP analysis. Abe K, Noguchi H, Tagawa K, Yuzuriha M, Toyoda A, Kojima T, Ezawa K, Saitou N, Hattori M, Sakaki Y, Moriwaki K, Shiroishi T Genome Res., 14, 2439-2447 (2004). 15574823Unique inbred strain MSM/Ms established from the Japanese wild mouse. Moriwaki K, Miyashita N, Mita A, Gotoh H, Tsuchiya K, Kato H, Mekada K, Noro C, Oota S, Yoshiki A, Obata Y, Yonekawa H, Shiroishi T Exp. Anim., 58, 123-134 (2009). 19448335Microsatellite database for MSM/Ms and JF1/Ms, molossinus-derived inbred strains. Kikkawa Y, Miura I, Takahama S, Wakana S, Yamazaki Y, Moriwaki K, Shiroishi T, Yonekawa H Mamm. Genome, 12, 750-752 (2001). 11641725Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits. Takada T, Mita A, Maeno A, Sakai T, Shitara H, Kikkawa Y, Moriwaki K, Yonekawa H, Shiroishi T Genome Res., 18, 500-508 (2008). 18256237Minisatellite instability in severe combined immunodeficiency mouse cells. Imai H, Nakagama H, Komatsu K, Shiraishi T, Fukuda H, Sugimura T, Nagao M Proc. Natl. Acad. Sci. USA, 94, 10817-10820 (1997). 9380717Immortalization of cells from brains derived from a strain (MSM/MSfB6C3F1) of wild mouse. Yuasa T, Abe E, Oshimura M, Namba M Acta Med. Okayama., 50, 319-324(1996). 8985469The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains. Takada T, Ebata T, Noguchi H, Keane T M, Adams D J, Narita T, Shin-I T, Fujisawa H, Toyoda A, Abe K, Obata Y, Sakaki Y, Moriwaki K, Fujiyama A, Kohara Y, Shiroishi T Genome Res., 23: 1329-1338 (2013). 23604024more 1 referencesEstablishment of germline-competent embryonic stem cell lines from the MSM/Ms strain. Araki K, Takeda N, Yoshiki A, Obata Y, Nakagata N, Shiroishi T, Moriwaki K, Yamamura K Mamm. Genome, 20, 14-20(2009). 19082856 |
Health Report | |
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Examination Date / Room / Rack | 2024/08/26Room:4-CRack:F 2024/05/27Room:4-CRack:F 2024/02/26Room:4-CRack:F 2023/11/27Room:4-CRack:F 2023/08/28Room:4-CRack:F 2023/05/29Room:4-CRack:F 2023/02/27Room:4-CRack:F 2022/11/29Room:4-CRack:F |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | Cancer Research Genetics Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. ① Exp. Anim., 58, 123-134 (2009). or/and ② Genome Res., 23: 1329–1338 (2013).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. (Contact info: Tsuyoshi Koide, Ph.D. <tkoide@nig.ac.jp>, Mouse Genomics Resource Laboratory) |
Depositor | Toshihiko Shiroishi (National Institute of Genetics) |
Strain Status | Live mice Frozen embryos Frozen sperm |
Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (1 to 3 months) |
Additional Info. | Necessary documents for ordering:
Mouse of the Month Apr 2009 Click Here for Mouse genomic DNA (RIKEN DNA Bank) Click Here for BAC clone (RIKEN DNA Bank) |
BRC mice in Publications |
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Kawakami M, Yamamura K. Cranial bone morphometric study among mouse strains. BMC Evol Biol 8 73(2008) 18307817 |
Hasegawa A, Mochida K, Matoba S, Inoue K, Hama D, Kadota M, Hiraiwa N, Yoshiki A, Ogura A. Development of assisted reproductive technologies for Mus spretus†. Biol Reprod 104(1) 234-243(2021) 32990726 |
Hasegawa A, Mochida K, Matoba S, Yonezawa K, Ohta A, Watanabe G, Taya K, Ogura A. Efficient production of offspring from Japanese wild-derived strains of mice (Mus musculus molossinus) by improved assisted reproductive technologies. Biol Reprod 86(5) 167, 1-7(2012) 22337332 |
Ikeda R, Shiura H, Numata K, Sugimoto M, Kondo M, Mise N, Suzuki M, Greally JM, Abe K. Large, male germ cell-specific hypomethylated DNA domains with unique genomic and epigenomic features on the mouse X chromosome. DNA Res 20(6) 549-65(2013) 23861320 |
Saito A, Tahara R, Hirose M, Kadota M, Hasegawa A, Kondo S, Kato H, Amano T, Yoshiki A, Ogura A, Kiyosawa H. Inter-subspecies mouse F1 hybrid embryonic stem cell lines newly established for studies of allelic imbalance in gene expression. Exp Anim (2024) 38447983 |
Omi N, Kiyokawa E, Matsuda M, Kinoshita K, Yamada S, Yamada K, Matsushima Y, Wang Y, Kawai J, Suzuki M, Hayashizaki Y, Hiai H. Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse. Exp Eye Res 86(5) 828-34(2008) 18396277 |
Mise N, Fuchikami T, Sugimoto M, Kobayakawa S, Ike F, Ogawa T, Tada T, Kanaya S, Noce T, Abe K. Differences and similarities in the developmental status of embryo-derived stem cells and primordial germ cells revealed by global expression profiling. Genes Cells 13(8) 863-77(2008) 18782224 |
Oka A, Mita A, Sakurai-Yamatani N, Yamamoto H, Takagi N, Takano-Shimizu T, Toshimori K, Moriwaki K, Shiroishi T. Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies. Genetics 166(2) 913-24(2004) 15020476 |
Kohama C, Kato H, Numata K, Hirose M, Takemasa T, Ogura A, Kiyosawa H. ES cell differentiation system recapitulates the establishment of imprinted gene expression in a cell-type-specific manner. Hum Mol Genet 21(6) 1391-401(2012) 22156770 |
Araki K, Takeda N, Yoshiki A, Obata Y, Nakagata N, Shiroishi T, Moriwaki K, Yamamura K. Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain. Mamm Genome 20(1) 14-20(2009) 19082856 |
Johnsen JM, Levy GG, Westrick RJ, Tucker PK, Ginsburg D. The endothelial-specific regulatory mutation, Mvwf1, is a common mouse founder allele. Mamm Genome 19(1) 32-40(2008) 18188647 |
Nunome M, Ishimori C, Aplin KP, Tsuchiya K, Yonekawa H, Moriwaki K, Suzuki H. Detection of recombinant haplotypes in wild mice (Mus musculus) provides new insights into the origin of Japanese mice. Mol Ecol 19(12) 2474-89(2010) 20465587 |
Shinmen A, Honda A, Ohkawa M, Hirose M, Ogonuki N, Yuzuriha M, Miki H, Mochida K, Inoue K, Abe K, Ito M, Ogura A. Efficient production of intersubspecific hybrid mice and embryonic stem cells by intracytoplasmic sperm injection. Mol Reprod Dev 74(9) 1081-8(2007) 17290420 |
Yagi M, Kabata M, Tanaka A, Ukai T, Ohta S, Nakabayashi K, Shimizu M, Hata K, Meissner A, Yamamoto T, Yamada Y. Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development. Nat Commun 11(1) 3199(2020) 32581223 |
Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Masuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa A, Abe K, Yoshimura T, Nabeshima T, Ebihara S. Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Nat Genet 41(6) 688-95(2009) 19465912 |
Yagi M, Kishigami S, Tanaka A, Semi K, Mizutani E, Wakayama S, Wakayama T, Yamamoto T, Yamada Y. Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation. Nature 548(7666) 224-227(2017) 28746308 |
Sugimoto M, Abe K. X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genet 3(7) e116(2007) 17676999 |
Mochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi M, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A. Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus. PLoS One 9(12) e114305(2014) 25470728 |
Hirose M, Hasegawa A, Mochida K, Matoba S, Hatanaka Y, Inoue K, Goto T, Kaneda H, Yamada I, Furuse T, Abe K, Uenoyama Y, Tsukamura H, Wakana S, Honda A, Ogura A. CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene. Sci Rep 7 42476(2017) 28195201 |
Yagi M, Kabata M, Ukai T, Ohta S, Tanaka A, Shimada Y, Sugimoto M, Araki K, Okita K, Woltjen K, Hochedlinger K, Yamamoto T, Yamada Y. De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency. Stem Cell Reports 12(5) 1113-1128(2019) 31056481 |