Strain Data Sheet

RBRC00186

Strain Information

Image
BRC No.RBRC00186
TypeInbred
SpeciesMus musculus
Strain nameDDK/Nga
Former Common name
H-2 Haplotype
ES Cell line
Background strainDDK
Appearancealbino [A/A B/B c/c D/D]
Strain developmentドイツマウス起源
Strain descriptionDerived from outbred dd stock from Institute Infectious Diseases, Universtiy of Tokyo. The DDK females mated to C57BL males are semi-sterile, but the reciprocal cross is fully fertile.
Colony maintenanceSibling Mating
References
A genetically determined incompatibility system between spermatozoa and eggs leading to embryonic death in mice.
Wakasugi N
J. Reprod. Fertil., 41, 85-96 (1974). 4431024

Characterization and chromosomal distribution of endogenous mouse mammary tumor viruses of European mouse strains STS/A and GR/A.
Michalides R, Verstraeten R, Shen F W, Hilgers J
Virology, 142, 278-290 (1985). 2997987

Tcrb-V3+ T-cell deletion and a new mouse mammary tumor provirus, Mtv-44.
Fairchild S, Rosenwasser O A, Dyson P J, Tomonari K
Immunogenetics, 36, 189-194 (1992). 1319398

The locus Om, responsible for the DDK syndrome, maps close to Sigje on mouse chromosome 11.
Baldacci P A, Richoux V, Renard J P, Guenet J L, Babinet C
Mamm. Genome, 2, 100-105 (1992). 1347470

A maternal factor affecting mouse blastocyst formation.
Renard J P, Baldacci P, Richoux-Duranthon V, Pournin S, Babinet C
Development, 120, 797-802 (1994). 7541334

Female mice of DDK strain are fully fertile in the intersubspecific crosses with Mus musculus molossinus and M. m. castaneus.
Zhao W D, Ishikawa A, Yamagata T, Bolor H, Wakasugi N
Mamm. Genome, 13, 345-351 (2002). 12140682

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Om
MGI:97434		ovum mutant11Om
Omlr
MGI:2149847		om-linked responder11Omlr

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal embryo development (MP:0001672)

  • abnormal female meiosis (MP:0005168)

  • abnormal trophoblast layer morphology (MP:0005031)

  • embryonic lethality before implantation, incomplete penetrance (MP:0011104)

  • maternal effect (MP:0003718)
    • more 2 phenotypes
  • reduced female fertility (MP:0001923)

  • transmission ratio distortion (MP:0004179)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationDevelopmental Biology Research
    Immunology and Inflammation Research
    Reproductive Biology Research
    Virology Research
    提供条件条件を付加しない。
    Depositor若杉　昇（名古屋大学）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data