Strain Data Sheet

RBRC00169

Strain Information

Image
BRC No.RBRC00169
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tnc<tm1Sia>/Rbrc
Former Common nameC57BL/6N-TgH(Tnc), B6-TN, TNKO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainC57BL/6NJcl
Appearanceblack [a/a, B/B, C/C]
Strain developmentSaga Y et al. (1992)により作成されたテネイシン欠損マウスを元に開発されたテネイシン欠損コンジェニック系統の一つ。
Strain description細胞外基質テネイシンの機能解析のためのテネシイン欠損マウス系統。C57BL/6NJcl系統は代表的な近交系。B6/NはB6/J よりも繁殖性が良好。創傷治癒の機構解析。細胞接着、細胞間相互作用。毛色は黒。
Colony maintenanceTnc(-/-)同士の兄妹交配。繁殖効率はA。実験群作出にはB6/N との交配必要。繁殖効率はB.
ReferencesJ. Neurosci., 15, 1971-1983 (1995). 7534342
Biochem. Biophys. Res. Commun., 221, 151-156 (1996). 8660327
Biochem. Biophys. Res. Commun., 231, 356-359 (1997). 9070278
Biochem. Biophys. Res. Commun., 290, 1220-1227 (2002). 11811993
J. Comp. Neurol., 430, 485-500 (2001). 11169482
Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999). 10235540
Perspect. Dev. Neurobiol., 2, 111-116 (1994). 7530137
Genes Dev., 6, 1821-1831 (1992). 1383086
Gene, 104, 177-185 (1991). 1717349
Jpn. J. Cancer Res., 93, 968-975 (2002). 12359049
J. Invest. Dermatol., 111, 930-935 (1998). 9856798
Exp. Mol. Pathol., 72, 186-195 (2002). 12009782
Am. J. Pathol., 152, 1237-1245 (1998). 9588892

Health Report

Examination Date / Room / Rack2022/04/25Room:3-CRack:K

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Tnctenascin C4Tnc<tm1Sia>targeted mutation 1, Shinichi AizawaTnc; tenascin C, Hxb, Ten, TN-C, AI528729

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
lacZbeta-galactosidase (E. coli)4

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)4neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Ordering Information

供与核酸E. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse tenascin genomic DNA
Research applicationNeurobiology Research
提供条件条件を付加する。
研究成果の公表にあたって寄託者の指定する文献を引用する。Am. J. Pathol., 152, 1237-1245 (1998). J. Invest. Dermatol., 111, 930-935 (1998). Invest. Ophthalmol. Visual. Sci., 1071-1080 (1999).
DepositorRIKEN BRC（独立行政法人理化学研究所）
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-
Genetic Background

BRC mice in Publications

Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasawa T, Suda T, Kubota Y.
Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration.
Blood 119(23) 5429-37(2012) 22553313

Xu M, Ye Z, Zhao X, Guo H, Gong X, Huang R.
Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
Cell Signal 86 110084(2021) 34271086

Imanaka-Yoshida K, Matsumoto K, Hara M, Sakakura T, Yoshida T.
The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse.
Differentiation 71(4-5) 291-8(2003) 12823230

Matsumoto K, Takahashi K, Yoshiki A, Kusakabe M, Ariga H.
Invasion of melanoma in double knockout mice lacking tenascin-X and tenascin-C.
Jpn J Cancer Res 93(9) 968-75(2002) 12359049

Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T.
Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress.
Proc Natl Acad Sci U S A 111(8) 3080-5(2014) 24516133

Kubo Y, Ishikawa K, Mori K, Kobayashi Y, Nakama T, Arima M, Nakao S, Hisatomi T, Haruta M, Sonoda KH, Yoshida S.
Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy.
Sci Rep 10(1) 9299(2020) 32518264