Strain Data Sheet

RBRC00169

Strain Information

Image
BRC No.RBRC00169
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tnc<tm1Sia>/Rbrc
Former Common nameC57BL/6N-TgH(Tnc), B6-TN, TNKO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainC57BL/6NJcl
Appearanceblack [a/a, B/B, C/C]
Strain developmentSaga Y et al. (1992)により作成されたテネイシン欠損マウスを元に開発されたテネイシン欠損コンジェニック系統の一つ。
Strain description細胞外基質テネイシンの機能解析のためのテネシイン欠損マウス系統。C57BL/6NJcl系統は代表的な近交系。B6/NはB6/J よりも繁殖性が良好。創傷治癒の機構解析。細胞接着、細胞間相互作用。毛色は黒。
Colony maintenanceTnc(-/-)同士の兄妹交配。繁殖効率はA。実験群作出にはB6/N との交配必要。繁殖効率はB.
References
Murine tenascin: cDNA cloning, structure and temporal expression of isoforms.
Saga Y, Tsukamoto T, Jing N, Kusakabe M, Sakakura T
Gene, 104, 177-185 (1991). 1717349

Mice develop normally without tenascin.
Saga Y, Yagi T, Ikawa Y, Sakakura T, Aizawa S
Genes Dev., 6, 1821-1831 (1992). 1383086

Can tenascin be redundant in cancer development?
Sakakura T, Kusakabe M
Perspect. Dev. Neurobiol., 2, 111-116 (1994). 7530137

Tenascin knockout mice: barrels, boundary molecules, and glial scars.
Steindler D A, Settles D, Erickson H P, Laywell E D, Yoshiki A, Faissner A, Kusakabe M
J. Neurosci., 15, 1971-1983 (1995). 7534342

Abnormal behavior and neurotransmissions of tenascin gene knockout mouse.
Fukamauchi F, Mataga N, Wang Y J, Sato S, Youshiki A, Kusakabe M
Biochem. Biophys. Res. Commun., 221, 151-156 (1996). 8660327

Tyrosine hydroxylase activity and its mRNA level in dopaminergic neurons of tenascin gene knockout mouse.
Fukamauchi F, Mataga N, Wang Y J, Sato S, Yoshiki A, Kusakabe M
Biochem. Biophys. Res. Commun., 231, 356-359 (1997). 9070278

Tenascin-C promotes healing of Habu-snake venom-induced glomerulonephritis: studies in knockout congenic mice and in culture.
Nakao N, Hiraiwa N, Yoshiki A, Ike F, Kusakabe M
Am. J. Pathol., 152, 1237-1245 (1998). 9588892

Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse.
Koyama Y, Kusubata M, Yoshiki A, Hiraiwa N, Ohashi T, Irie S, Kusakabe M
J. Invest. Dermatol., 111, 930-935 (1998). 9856798

Corneal wound healing in tenascin knockout mouse.
Matsuda A, Yoshiki A, Tagawa Y, Matsuda H, Kusakabe M
Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999). 10235540

Loss of cortical and thalamic neuronal tenascin-C expression in a transgenic mouse expressing exon 1 of the human Huntington disease gene.
Kusakabe M, Mangiarini L, Laywell E D, Bates G P, Yoshiki A, Hiraiwa N, Inoue J, Steindler D A
J. Comp. Neurol., 430, 485-500 (2001). 11169482
more 3 references
PDGF receptor-alpha deficiency in glomerular mesangial cells of tenascin-C knockout mice.
Matsumoto K, Hiraiwa N, Yoshiki A, Ohnishi M, Kusakabe M
Biochem. Biophys. Res. Commun., 290, 1220-1227 (2002). 11811993

Invasion of melanoma in double knockout mice lacking tenascin-X and tenascin-C.
Matsumoto K, Takahashi K, Yoshiki A, Kusakabe M, Ariga H
Jpn. J. Cancer Res., 93, 968-975 (2002). 12359049

Tenascin-C expression and splice variant in habu snake venom-induced glomerulonephritis.
Matsumoto K, Hiraiwa N, Yoshiki A, Ohnishi M, Kusakabe M
Exp. Mol. Pathol., 72, 186-195 (2002). 12009782

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tnc
MGI:101922		tenascin C4Tnc<tm1Sia>
MGI:2148540		targeted mutation 1, Shinichi Aizawa
  • autosomal dominant nonsyndromic hearing loss 56(MedGEN)
    • lacZ beta-galactosidase (E. coli)4
    neo neomycin resistance gene (E. coli)4 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal CNS synaptic transmission (MP:0002206)

  • abnormal circadian behavior (MP:0020467)

  • abnormal serotonin level (MP:0005322)

  • decreased dopamine level (MP:0005643)

  • hyperactivity (MP:0001399)
    • more 3 phenotypes
  • impaired swimming (MP:0001522)

  • increased stereotypic behavior (MP:0001409)

  • no abnormal phenotype detected (MP:0002169)
    • Detailed phenotype data

    Ordering Information

    供与核酸E. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse tenascin genomic DNA
    Research applicationNeurobiology Research
    提供条件研究成果の公表にあたって寄託者の指定する文献を引用する。Am. J. Pathol., 152, 1237-1245 (1998). J. Invest. Dermatol., 111, 930-935 (1998). Invest. Ophthalmol. Visual. Sci., 1071-1080 (1999).
    DepositorRIKEN BRC（独立行政法人理化学研究所）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Yonemura A, Semba T, Zhang J, Fan Y, Yasuda-Yoshihara N, Wang H, Uchihara T, Yasuda T, Nishimura A, Fu L, Hu X, Wei F, Kitamura F, Akiyama T, Yamashita K, Eto K, Iwagami S, Iwatsuki M, Miyamoto Y, Matsusaki K, Yamasaki J, Nagano O, Saya H, Song S, Tan P, Baba H, Ajani JA, Ishimoto T.
    Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment.
    Cell Rep 43(1) 113613(2024) 38232734
    Moriyama M, Nakamura K, Nagata H, Wada I, Nagira K, Azuma Y, Sato E, Harada T, Taniguchi F.
    Role of tenascin C in lesion formation in early peritoneal endometriosis.
    F S Sci 5(1) 69-79(2024) 38092313
    Tashjian RZ, Zitnay J, Kazmers NH, Veerabhadraiah SR, Zelada AC, Honeggar M, Smith MC, Chalmers PN, Henninger HB, Jurynec MJ.
    Tenascin C deletion impairs tendon healing and functional recovery after rotator cuff repair.
    J Orthop Res (2024) 39601211
    Xu M, Ye Z, Zhao X, Guo H, Gong X, Huang R.
    Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
    Cell Signal 86 110084(2021) 34271086
    Kubo Y, Ishikawa K, Mori K, Kobayashi Y, Nakama T, Arima M, Nakao S, Hisatomi T, Haruta M, Sonoda KH, Yoshida S.
    Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy.
    Sci Rep 10(1) 9299(2020) 32518264
    Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T.
    Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress.
    Proc Natl Acad Sci U S A 111(8) 3080-5(2014) 24516133
    Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasawa T, Suda T, Kubota Y.
    Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration.
    Blood 119(23) 5429-37(2012) 22553313
    Imanaka-Yoshida K, Matsumoto K, Hara M, Sakakura T, Yoshida T.
    The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse.
    Differentiation 71(4-5) 291-8(2003) 12823230
    Matsumoto K, Takahashi K, Yoshiki A, Kusakabe M, Ariga H.
    Invasion of melanoma in double knockout mice lacking tenascin-X and tenascin-C.
    Jpn J Cancer Res 93(9) 968-75(2002) 12359049