Strain Data Sheet

RBRC00165

Strain Information

Image
BRC No.RBRC00165
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Zic2<tm1Jaru>/JaruRbrc
Former Common nameC57BL/6N-Kd(Zic2), Zic2 Knockdown mouse
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strainC57BL/6N
Appearanceblack
Strain development
Strain description
Colony maintenance
References
Zic2 regulates the kinetics of neurulation.
Nagai T, Aruga J, Minowa O, Sugimoto T, Ohno Y, Noda T, Mikoshiba K
Proc. Natl. Acad. Sci. USA, 97, 1618-1623 (2000). 10677508

Zic2 controls cerebellar development in cooperation with Zic1.
Aruga J, Inoue T, Hoshino J, Mikoshiba K
J. Neurosci., 22, 218-225 (2002). 11756505

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Zic2
MGI:106679		zinc finger protein of the cerebellum 214Zic2<tm1Jaru>
MGI:2156825		targeted mutation 1, Jun Aruga
  • holoprosencephaly 5(DisGeNET, MedGEN)
    • neo neomycin resistance gene (E. coli)14 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal amygdala morphology (MP:0000818)

  • abnormal autopod morphology (MP:0000572)

  • abnormal brain development (MP:0000913)

  • abnormal cerebral cortex morphology (MP:0000788)

  • abnormal cerebral hemisphere morphology (MP:0008540)
    • more 40 phenotypes
  • abnormal dorsal root ganglion morphology (MP:0000961)

  • abnormal forebrain development (MP:0003232)

  • abnormal limb bone morphology (MP:0002115)

  • abnormal nervous system development (MP:0003861)

  • abnormal neural fold formation (MP:0004837)

  • abnormal neural plate morphology (MP:0005657)

  • abnormal neural tube morphology (MP:0002151)

  • abnormal olfactory bulb morphology (MP:0000819)

  • abnormal roof plate morphology (MP:0000923)

  • abnormal spatial learning (MP:0001463)

  • abnormal spatial working memory (MP:0008428)

  • abnormal spinal cord dorsal horn morphology (MP:0006282)

  • abnormal telencephalon development (MP:0000934)

  • abnormal vertebral arch morphology (MP:0004599)

  • anencephaly (MP:0001890)

  • behavior/neurological phenotype (MP:0005386)

  • curly tail (MP:0003051)

  • decreased aggression towards mice (MP:0003863)

  • decreased brain size (MP:0000774)

  • decreased corpus callosum size (MP:0000781)

  • decreased locomotor activity (MP:0001402)

  • decreased neuron number (MP:0008948)

  • decreased prepulse inhibition (MP:0009142)

  • enlarged lateral ventricles (MP:0008535)

  • exencephaly (MP:0000914)

  • fused carpal bones (MP:0008915)

  • fused metacarpal bones (MP:0004639)

  • fused metatarsal bones (MP:0004642)

  • fused tarsal bones (MP:0008919)

  • fusion of vertebral arches (MP:0004613)

  • hindlimb paralysis (MP:0000755)

  • holoprosencephaly (MP:0005157)

  • hyperactivity (MP:0001399)

  • impaired contextual conditioning behavior (MP:0009454)

  • impaired cued conditioning behavior (MP:0009456)

  • increased startle reflex (MP:0001488)

  • microcephaly (MP:0000433)

  • postnatal lethality, complete penetrance (MP:0011085)

  • spina bifida (MP:0003054)

  • thin cerebral cortex (MP:0006254)
    • Detailed phenotype data

    Ordering Information

    供与核酸mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Zic2 (Zic finger protein of the cerebellum 2) genomic DNA
    Research applicationNeurobiology Research
    提供条件利用者は事前に寄託者の提供承諾書を得る。研究成果の公表にあたって寄託者の指定する文献を引用する。Proc. Natl. Acad. Sci. USA, 97, 1618-1623 (2000).
    Depositor有賀　純（理化学研究所脳科学総合研究センター）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP

    BRC mice in Publications

    Barnada SM, Giner de Gracia A, Morenilla-Palao C, López-Cascales MT, Scopa C, Waltrich FJ Jr, Mikkers HMM, Cicardi ME, Karlin J, Trotti D, Peterson KA, Brugmann SA, Santen GWE, McMahon SB, Herrera E, Trizzino M.
    ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification.
    Am J Hum Genet 111(10) 2232-2252(2024) 39226899
    Sánchez-Arrones L, Nieto-Lopez F, Sánchez-Camacho C, Carreres MI, Herrera E, Okada A, Bovolenta P.
    Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina.
    J Neurosci 33(20) 8596-607(2013) 23678105
    García-Frigola C, Herrera E.
    Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets.
    EMBO J 29(18) 3170-83(2010) 20676059
    García-Frigola C, Carreres MI, Vegar C, Mason C, Herrera E.
    Zic2 promotes axonal divergence at the optic chiasm midline by EphB1-dependent and -independent mechanisms.
    Development 135(10) 1833-41(2008) 18417618