Strain Data Sheet



BRC No.RBRC00165
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Zic2<tm1Jaru>/JaruRbrc
Former Common nameC57BL/6N-Kd(Zic2), Zic2 Knockdown mouse
H-2 Haplotype
ES Cell line
Background strainC57BL/6N
Strain development
Strain description
Colony maintenance
ReferencesJ. Neurosci., 22, 218-225 (2002). 11756505
Proc. Natl. Acad. Sci. USA, 97, 1618-1623 (2000). 10677508

Health Report

Examination Date / Room / RackNo Data


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Zic2zinc finger protein of the cerebellum 214Zic2<tm1Jaru>targeted mutation 1, Jun Aruga

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)14neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)


Donor DNAmouse Zic2 (Zic finger protein of the cerebellum 2) genomic DNA, E. coli neo, mouse phosphoglycerate kinase promoter (PGK promoter)
Research applicationNeurobiology Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 97, 1618-1623 (2000).
DepositorJun Aruga (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP

BRC mice in Publications

Garc a-Frigola C, Carreres MI, Vegar C, Mason C, Herrera E.
Zic2 promotes axonal divergence at the optic chiasm midline by EphB1-dependent and -independent mechanisms.
Development 135(10) 1833-41(2008) 18417618

Garc a-Frigola C, Herrera E.
Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets.
EMBO J. 29(18) 3170-83(2010) 20676059

S nchez-Arrones L, Nieto-Lopez F, S nchez-Camacho C, Carreres MI, Herrera E, Okada A, Bovolenta P.
Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina.
J. Neurosci. 33(20) 8596-607(2013) 23678105