Strain Data Sheet

RBRC00152

Strain Information

Image
BRC No.RBRC00152
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Ryr3<tm1Jms>/Rbrc
Former Common nameC57BL/6-TgH(RyR3)
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6
Appearanceblack [a/a]
Strain development
Strain description
Colony maintenance
References
Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3.
Futatsugi A, Kato K, Ogura H, Li S T, Nagata E, Kuwajima G, Tanaka K, Itohara S, Mikoshiba K
Neuron, 24, 701-13 (1999). 10595520

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ryr3ryanodine receptor 32Ryr3targeted mutation 1, Institute of Medical Science, Japan
neoneomycin resistance gene (E. coli)2mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal spatial learning(MP:0001463)

  • absent long-term depression(MP:0001899)

  • enhanced long-term potentiation(MP:0003008)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Ryanodine receptor type3 (RyR3) genomic DNA
    Research applicationCell Biology Research
    Neurobiology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers.
    DepositorKatsuhiko Mikoshiba (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data