Strain Data Sheet

RBRC00142

Strain Information

Image
BRC No.RBRC00142
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameB6.Cg-Kit<W-v>/Rbrc
Former Common nameC57BL/6-Kit<W-v>/+
H-2 Haplotype
ES Cell line
Background strain
Appearancewhite with black eyes [a/a B/B C/C W/W]
black [a/a B/B C/C +/+]
gray with light belly, white spot, light tail an feet [a/a B/B C/C W/+]
Strain developmentSpontaneous mutation arosed in C57BL.
Strain descriptionB6.Cg-Kit<W-v>. Viable dominant spotting. Spontaneous mutation arosed in C57BL. The Kit<W-v> mutation arose spontaneously in the C57BL strain. Heterozygote for Kit<W-v> are gray with light belly, white spot, light tail and feet. Homozygous mice are white with black eyes. The c-Kit cDNA from Kit<W-v>/Kit<W-v> mice showed an AC to T point mutation at nucleotide 2007 that resulted in the change from threonine to methionine at position 660.
Colony maintenanceSibling Mating (Heterozygote x Wild-type or Heterozygote)
References
Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv).
Arguello F, Furlanetto R W, Baggs R B, Graves B T, Harwell S E, Cohen H J, Frantz C N
Cancer Res., 52, 2304-2309 (1992). 1559233

A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis.
Shyu H W, Hsu S H, Hsieh-Li H M, Li H
Mech. Dev., 108, 213-216 (2001). 11578878

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Kit
MGI:96677		KIT proto-oncogene receptor tyrosine kinase5Kit<W-v>
MGI:1856266		viable dominant spotting
  • acute myeloid leukemia(DisGeNET, MedGEN)

  • cutaneous mastocytosis(MedGEN)

  • gastrointestinal stromal tumor(DisGeNET, MedGEN)
    • more 3 Diseases
  • mastocytosis(DisGeNET)

  • piebaldism(DisGeNET, MedGEN)

  • testicular germ cell tumor(MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal body temperature (MP:0005535)

  • abnormal coat/hair pigmentation (MP:0002075)

  • abnormal cochlea morphology (MP:0000031)

  • abnormal cochlear ganglion morphology (MP:0002855)

  • abnormal cochlear outer hair cell morphology (MP:0004399)
    • more 29 phenotypes
  • abnormal ear pigmentation (MP:0000015)

  • abnormal histamine physiology (MP:0002503)

  • abnormal melanocyte morphology (MP:0002877)

  • abnormal melanosome morphology (MP:0005075)

  • abnormal organ of Corti morphology (MP:0000042)

  • abnormal otolith morphology (MP:0002894)

  • abnormal stria vascularis morphology (MP:0000048)

  • abnormal stria vascularis vasculature morphology (MP:0004368)

  • abnormal strial basal cell morphology (MP:0004365)

  • abnormal strial marginal cell morphology (MP:0004366)

  • abnormal tectorial membrane morphology (MP:0003149)

  • abnormal vestibular saccule morphology (MP:0006089)

  • absent endocochlear potential (MP:0004410)

  • absent strial intermediate cells (MP:0006010)

  • belly spot (MP:0000373)

  • cochlear ganglion degeneration (MP:0002857)

  • decreased erythrocyte cell number (MP:0002875)

  • decreased mast cell number (MP:0000336)

  • decreased susceptibility to type I hypersensitivity reaction (MP:0005597)

  • diluted coat color (MP:0000371)

  • enlarged otoliths (MP:0003143)

  • head spot (MP:0002939)

  • increased bleeding time (MP:0005606)

  • macrocytic anemia (MP:0002811)

  • reduced fertility (MP:0001921)

  • thin stria vascularis (MP:0004364)

  • variable body spotting (MP:0002940)

  • vestibular hair cell degeneration (MP:0004324)

  • white spotting (MP:0002938)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationDevelopmental Biology Research
    Immunology and Inflammation Research
    Mouse Models for Human Disease
    Neurobiology Research
    Reproductive Biology Research
    Sensorineural Research
    提供条件条件を付加しない。
    Depositor北村　幸彦（大阪大学）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data