RBRC00142

Information1

Image
BRC No.RBRC00142
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameB6.Cg-Kit<W-v>/Rbrc
Former Common nameC57BL/6-KitW-v/+
H-2 Haplotype
ES Cell line
Background strain
Appearancegray with light belly, white spot, light tail an feet [a/a B/B C/C W/+]
black [a/a B/B C/C +/+]
white with black eyes [a/a B/B C/C W/W]
Strain developmentSpontaneous mutation arosed in C57BL.
Strain descriptionB6.Cg-Kit<W-v>. Viable dominant spotting. Spontaneous mutation arosed in C57BL. The Kit<W-v> mutation arose spontaneously in the C57BL strain. Heterozygote for Kit<W-v> are gray with light belly, white spot, light tail and feet. Homozygous mice are white with black eyes. The c-Kit cDNA from Kit<W-v>/Kit<W-v> mice showed an AC to T point mutation at nucleotide 2007 that resulted in the change from threonine to methionine at position 660.
Colony maintenanceSibling Mating (Heterozygote x Wild-type or Heterozygote)
ReferencesMech. Dev., 108, 213-216 (2001). 11578878
Cancer Res., 52, 2304-2309 (1992). 1559233

Health Report

Examination Date / Room / Rack2007/04/02Room:3-6Rack:C
2007/02/05Room:3-6Rack:C
2006/12/04Room:3-6Rack:C
2006/10/02Room:3-6Rack:C
2006/08/08Room:3-6Rack:C
2006/08/07Room:3-6Rack:C
2006/06/06Room:3-6Rack:C
2006/04/04Room:3-6Rack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Kitkit oncogene5Kit<W-v>viable dominant spotting

Information2

Donor DNA
Research applicationDevelopmental Biology Research
Immunology and Inflammation Research
Mouse Models for Human Disease
Neurobiology Research
Reproductive Biology Research
Sensorineural Research
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorYukihiko Kitamura (Osaka University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

No Data