Strain Data Sheet

RBRC00135

Strain Information

Image
BRC No.RBRC00135
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameB6.Cg-Lyst<bg-J> Foxn1<nu>/StmRbrc
Former Common nameC57BL/6J-bg/bg-Foxn1<nu>
H-2 Haplotype
ES Cell line
Background strainC57BL/6J
Appearanceblack
Strain development
Strain description
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Foxn1
MGI:102949		forkhead box N111Foxn1<nu>
MGI:1856108		nude
  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy(DisGeNET, MedGEN)

  • T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant(MedGEN)
    • Lyst
    MGI:107448    		lysosomal trafficking regulator13Lyst<bg-J>
    MGI:1855969    		beige Jackson
  • Chediak-Higashi syndrome(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal Peyer's patch germinal center morphology(MP:0002391)

  • abnormal T cell activation(MP:0001828)

  • abnormal anterior uvea morphology(MP:0005194)

  • abnormal circulating cytokine level(MP:0010210)

  • abnormal circulating gonadotropin level(MP:0003361)
    • more 98 phenotypes
  • abnormal coat/ hair morphology(MP:0000367)

  • abnormal compact bone morphology(MP:0003797)

  • abnormal corneocyte morphology(MP:0030605)

  • abnormal cutaneous collagen fibril morphology(MP:0008438)

  • abnormal embryonic tissue morphology(MP:0002085)

  • abnormal epidermal layer morphology(MP:0001216)

  • abnormal epidermis stratum basale morphology(MP:0001231)

  • abnormal epidermis stratum corneum morphology(MP:0001240)

  • abnormal epidermis stratum granulosum morphology(MP:0001239)

  • abnormal estrous cycle(MP:0001927)

  • abnormal eye anterior chamber morphology(MP:0005205)

  • abnormal gait(MP:0001406)

  • abnormal granulocyte morphology(MP:0002441)

  • abnormal hair cortex keratinization(MP:0009801)

  • abnormal hair cortex morphology(MP:0003811)

  • abnormal hair cuticle(MP:0003810)

  • abnormal hair follicle inner root sheath morphology(MP:0010685)

  • abnormal hair follicle morphology(MP:0000377)

  • abnormal hair shaft morphology(MP:0003809)

  • abnormal iridocorneal angle(MP:0004221)

  • abnormal iris morphology(MP:0001322)

  • abnormal iris pigment epithelium(MP:0005199)

  • abnormal iris pigmentation(MP:0005102)

  • abnormal iris stroma morphology(MP:0005208)

  • abnormal liver morphology(MP:0000598)

  • abnormal lymph node T cell domain morphology(MP:0002347)

  • abnormal lymph node morphology(MP:0002339)

  • abnormal muscle morphology(MP:0002108)

  • abnormal nail matrix morphology(MP:0012405)

  • abnormal nail morphology(MP:0000579)

  • abnormal nail plate morphology(MP:0012403)

  • abnormal neutrophil morphology(MP:0005065)

  • abnormal spleen morphology(MP:0000689)

  • abnormal spleen physiology(MP:0008737)

  • abnormal splenic cell ratio(MP:0008826)

  • abnormal thymus development(MP:0000704)

  • abnormal thymus morphology(MP:0000703)

  • abnormal trabecular bone morphology(MP:0000130)

  • abnormal venule morphology(MP:0004125)

  • abnormal vestibuloocular reflex(MP:0004844)

  • absent vibrissae(MP:0001284)

  • ascites(MP:0005324)

  • asthenozoospermia(MP:0002675)

  • athymia(MP:0000705)

  • blepharitis(MP:0005251)

  • chromosomal instability(MP:0008866)

  • coiled sperm flagellum(MP:0009238)

  • decreased Purkinje cell number(MP:0000880)

  • decreased T cell number(MP:0005018)

  • decreased body size(MP:0001265)

  • decreased body weight(MP:0001262)

  • decreased circulating alanine transaminase level(MP:0002942)

  • decreased circulating follicle stimulating hormone level(MP:0002790)

  • decreased circulating interleukin-2 level(MP:0008600)

  • decreased circulating interleukin-6 level(MP:0008597)

  • decreased circulating luteinizing hormone level(MP:0002773)

  • decreased circulating tumor necrosis factor level(MP:0008554)

  • decreased interferon-gamma secretion(MP:0008567)

  • decreased leukocyte cell number(MP:0000221)

  • decreased lymphocyte cell number(MP:0005016)

  • decreased lysosomal enzyme secretion(MP:0003173)

  • decreased macrophage cell number(MP:0003884)

  • decreased platelet ADP level(MP:0009557)

  • decreased platelet ATP level(MP:0009448)

  • decreased platelet serotonin level(MP:0004725)

  • decreased skeletal muscle fiber size(MP:0009400)

  • decreased skeletal muscle mass(MP:0004819)

  • decreased susceptibility to bacterial infection(MP:0002411)

  • decreased susceptibility to parasitic infection(MP:0005026)

  • deformed nails(MP:0000580)

  • endocrine/exocrine gland phenotype(MP:0005379)

  • female infertility(MP:0001926)

  • hairless(MP:0003815)

  • impaired balance(MP:0001525)

  • impaired natural killer cell mediated cytotoxicity(MP:0005070)

  • impaired spatial learning(MP:0012307)

  • impaired swimming(MP:0001522)

  • increased bleeding time(MP:0005606)

  • increased bone mineral density(MP:0000062)

  • increased length of allograft survival(MP:0004751)

  • increased plasmacytoma incidence(MP:0010286)

  • increased susceptibility to viral infection induced morbidity/mortality(MP:0009791)

  • increased susceptibility to viral infection(MP:0002418)

  • nail dystrophy(MP:0012400)

  • paraparesis(MP:0009434)

  • postnatal growth retardation(MP:0001732)

  • postnatal lethality, incomplete penetrance(MP:0011086)

  • premature death(MP:0002083)

  • reduced hair shaft melanin granule number(MP:0008732)

  • reduced male fertility(MP:0001922)

  • short nails(MP:0012399)

  • short vibrissae(MP:0001282)

  • small ovary(MP:0001127)

  • small spleen(MP:0000692)

  • thin skin(MP:0001199)

  • tremors(MP:0000745)

  • vision/eye phenotype(MP:0005391)

  • wavy vibrissae(MP:0001279)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorHayase Shisa (Saitama Cancer Center)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data