Strain Data Sheet

RBRC00134

Strain Information

Image
BRC No.RBRC00134
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameC57BL/6-Lyst<bg-J>/StmRbrc
Former Common nameC57BL/6-bg/bg
H-2 Haplotypeb
ES Cell line
Background strainC57BL/6J
Appearancelight black [aaBBCC;bgJ/bgJ]
Strain developmentジャクソン研究所 ー 愛知がんセンター（1973?）ー 埼玉県立がんセンター（1977, F16）ー 理化学研究所（筑波）（F85）。
Strain descriptionBeige自然突然変異マウス。Chediac-Higashi病のモデル。NK細胞活性低下、メラノサイト、好中球、リンパ球などの細胞質に巨大顆粒が認められる。
Colony maintenanceHomozygote x Homozygote
References
Identification of the homologous beige and Chediak-Higashi syndrome genes.
M D Barbosa, Q A Nguyen, V T Tchernev, J A Ashley, J C Detter, S M Blaydes, S J Brandt, D Chotai, C Hodgman, R C Solari, M Lovett, S F Kingsmore
Nature, 382, 262-265 (1996). 8717042

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Lyst
MGI:107448		lysosomal trafficking regulator13Lyst<bg-J>
MGI:1855969		beige Jackson
  • Chediak-Higashi syndrome(DisGeNET, MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal anterior uvea morphology (MP:0005194)

  • abnormal eye anterior chamber morphology (MP:0005205)

  • abnormal gait (MP:0001406)

  • abnormal granulocyte morphology (MP:0002441)

  • abnormal iridocorneal angle (MP:0004221)
    • more 18 phenotypes
  • abnormal iris morphology (MP:0001322)

  • abnormal iris pigment epithelium (MP:0005199)

  • abnormal iris pigmentation (MP:0005102)

  • abnormal iris stroma morphology (MP:0005208)

  • abnormal neutrophil morphology (MP:0005065)

  • abnormal vestibuloocular reflex (MP:0004844)

  • decreased Purkinje cell number (MP:0000880)

  • decreased lysosomal enzyme secretion (MP:0003173)

  • decreased macrophage cell number (MP:0003884)

  • decreased platelet ADP level (MP:0009557)

  • decreased platelet ATP level (MP:0009448)

  • decreased platelet serotonin level (MP:0004725)

  • impaired balance (MP:0001525)

  • impaired natural killer cell mediated cytotoxicity (MP:0005070)

  • impaired swimming (MP:0001522)

  • increased bleeding time (MP:0005606)

  • paraparesis (MP:0009434)

  • tremors (MP:0000745)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationDermatology Research
    Hematological Research
    Immunology and Inflammation Research
    Internal/Organ Research
    Metabolism Research
    Mouse Models for Human Disease
    提供条件条件を付加しない。
    Depositor志佐　湍（埼玉県立がんセンター研究所）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Yoshino T, Miyazaki J, Kojima T, Kandori S, Shiga M, Kawahara T, Kimura T, Naka T, Kiyohara H, Watanabe M, Yamasaki S, Akaza H, Yano I, Nishiyama H.
    Cationized liposomal keto-mycolic acids isolated from Mycobacterium bovis bacillus Calmette-Guérin induce antitumor immunity in a syngeneic murine bladder cancer model.
    PLoS One 14(1) e0209196(2019) 30608942