Strain Data Sheet

RBRC00117

Strain Information

Image
BRC No.RBRC00117
TypeMajor Histocompatibility Complex (H2) Congenic
SpeciesMus musculus
Strain nameC57BL/6JBoy-H2<k>
Former Common name
H-2 Haplotypek
ES Cell line
Background strainC57BL/6JBoy
Appearanceblack
Strain development
Strain description
Colony maintenance
References
Immunogenetics of cell surface antigens of mouse leukemia.
Old L J, Stockert E
Ann. Rev. Genet., 11, 127 (1977). 202188

Inbred and Genetically defined strains of laboratory animals, Part 1 Mouse and Rat (1979). ISBN0913822124

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
H2histocompatibility-2, MHC17H2k variant

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal negative T cell selection(MP:0004918)

  • decreased CD8-positive, alpha-beta T cell number(MP:0008079)

  • decreased susceptibility to autoimmune diabetes(MP:0004804)

  • increased CD4-positive, alpha-beta T cell number(MP:0008074)

  • increased physiological sensitivity to xenobiotic(MP:0008873)
  • more 3 phenotypes
  • increased susceptibility to autoimmune diabetes(MP:0004803)

  • periinsulitis(MP:0005580)

  • small thymus(MP:0000706)
  • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorToshitada Takahashi (Aichi Cancer Center)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data