Strain Data Sheet

RBRC00113

Strain Information

Image
BRC No.RBRC00113
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameC3H/HeSn-Ttf/+tf
Former Common nameC3H/HeSn-Ttf/+tf
H-2 Haplotype
ES Cell line
Background strainC3H
Appearanceagouti, tail defects, tufted (A/A, T tf/+tf)
agouti, tufted (A/A, + tf/+tf)
Strain developmentC3H/HeSn-Ttf/+tf strain was introduced to National Institute of Genetics from the Jackson laboratory in 1985.
Strain descriptionT, Brachyury, semidominant, Chr 17. Discovered in a laboratory stock. T/T homozygous embryos die at 10 days of gestation due to failure to form a normal mesoderm. T/+ heterozygote have a shortened tail and abnormal sacral vertebrae. T/t mice are tailless. tf/tf homozygous mice show repeated waves of hair loss and regrowth. tf gene is linked to the T/t complex.
Colony maintenanceshort tail x normal tail
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Itpr3
MGI:96624		inositol 1,4,5-triphosphate receptor 317Itpr3<tf>
MGI:1857070		tufted
  • type 1 diabetes mellitus(MedGEN)
    • T
    MGI:98472    		brachyury, T-box transcription factor T17T
    MGI:1856184    		brachyury
  • neural tube defect(MedGEN)

  • sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome(MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal allogrooming behavior (MP:0011000)

  • abnormal brain commissure morphology (MP:0002199)

  • abnormal cerebral cortex morphology (MP:0000788)

  • abnormal coat/ hair morphology (MP:0000367)

  • abnormal dorsal aorta morphology (MP:0004787)
    • more 45 phenotypes
  • abnormal epidermal layer morphology (MP:0001216)

  • abnormal forelimb bud morphology (MP:0013164)

  • abnormal gustatory system physiology (MP:0001985)

  • abnormal hair cycle (MP:0000427)

  • abnormal hair growth (MP:0002073)

  • abnormal head shape (MP:0011495)

  • abnormal heart looping (MP:0000269)

  • abnormal heart tube morphology (MP:0000270)

  • abnormal limb bud morphology (MP:0005650)

  • abnormal liquid preference (MP:0001423)

  • abnormal locomotor activation (MP:0003313)

  • abnormal neocortex morphology (MP:0008547)

  • abnormal nervous system development (MP:0003861)

  • abnormal neural tube morphology (MP:0002151)

  • abnormal pericardial cavity morphology (MP:0012501)

  • abnormal placenta development (MP:0001712)

  • abnormal primitive streak formation (MP:0002230)

  • abnormal social investigation (MP:0001360)

  • abnormal somite development (MP:0001688)

  • abnormal vocalization (MP:0001529)

  • absent corpus callosum (MP:0002196)

  • absent hindlimb buds (MP:0013168)

  • absent notochord (MP:0000932)

  • bleb (MP:0008854)

  • caudal body truncation (MP:0004073)

  • decreased anterior commissure size (MP:0008226)

  • decreased anxiety-related response (MP:0001364)

  • decreased embryo size (MP:0001698)

  • decreased hippocampal commissure size (MP:0008222)

  • delayed heart development (MP:0012082)

  • embryonic lethality during organogenesis, complete penetrance (MP:0011098)

  • excessive vocalization (MP:0013140)

  • hemopericardium (MP:0005244)

  • hemorrhage (MP:0001914)

  • impaired social transmission of food preference (MP:0002969)

  • increased body weight (MP:0001260)

  • increased fluid intake (MP:0011941)

  • increased grooming behavior (MP:0001441)

  • increased growth rate (MP:0002865)

  • kinked neural tube (MP:0003400)

  • limbs/digits/tail phenotype (MP:0005371)

  • low sweet preference (MP:0012347)

  • notochord degeneration (MP:0004712)

  • short tail (MP:0000592)

  • sparse hair (MP:0000416)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationDermatology Research
    Developmental Biology Research
    提供条件条件を付加しない。
    Depositor城石　俊彦（国立遺伝学研究所）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Hatakeyama Y, Saito N, Mii Y, Takada R, Shinozuka T, Takemoto T, Naoki H, Takada S.
    Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis.
    Nat Commun 14(1) 1924(2023) 37024462