Strain Information | |
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Image | |
BRC No. | RBRC00113 |
Type | Spontaneous Mutation Congenic |
Species | Mus musculus |
Strain name | C3H/HeSn-Ttf/+tf |
Former Common name | C3H/HeSn-Ttf/+tf |
H-2 Haplotype | |
ES Cell line | |
Background strain | C3H |
Appearance | agouti, tail defects, tufted (A/A, T tf/+tf) agouti, tufted (A/A, + tf/+tf) |
Strain development | C3H/HeSn-Ttf/+tf strain was introduced to National Institute of Genetics from the Jackson laboratory in 1985. |
Strain description | T, Brachyury, semidominant, Chr 17. Discovered in a laboratory stock. T/T homozygous embryos die at 10 days of gestation due to failure to form a normal mesoderm. T/+ heterozygote have a shortened tail and abnormal sacral vertebrae. T/t mice are tailless. tf/tf homozygous mice show repeated waves of hair loss and regrowth. tf gene is linked to the T/t complex. |
Colony maintenance | Sister-brother matingHeterozygote x Wild (tail defects x normal tail) |
References |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Itpr3 | inositol 1,4,5-triphosphate receptor 3 | 17 | Itpr3 | tufted | |||
T | brachyury, T-box transcription factor T | 17 | T | brachyury |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 45 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | Dermatology Research Developmental Biology Research |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | Toshihiko Shiroishi (National Institute of Genetics) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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Hatakeyama Y, Saito N, Mii Y, Takada R, Shinozuka T, Takemoto T, Naoki H, Takada S. Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis. Nat Commun 14(1) 1924(2023) 37024462 |