Strain Data Sheet

RBRC00110

Strain Information

Image
BRC No.RBRC00110
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC3.Cg-Tnc<tm1Sia>/Rbrc
Former Common nameC3H/HeN-TgH(Tnc), C3H-TN, TNKO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainC3H/HeNCrlCrlj
Appearance
Strain developmentSaga Y et al. (1992)により作成されたテネイシン欠損マウスにおいて発生に異常が認められず、テネイシン機能の重要性が疑われた。遺伝背景の影響が大きいと考え、代表的近交系マウスへのコンジェニック化を1991年から開始した。開発者：日下部守昭先生。真核生物研究室所属当時から開発を開始。Tnc(-/-)同士の兄妹交配。繁殖効率はA。実験群作出にはB6/N との交配必要。繁殖効率はB.
Strain description細胞外基質テネイシンの機能解析のためのテネシイン欠損マウス系統。C3H/HeNCrj系統は代表的な近交系。MMTVによる乳癌高発系統。肝癌の発生率も高い。癌の増殖、転移機構におけるテネイシン機能の解析。創傷治癒の機構解析。細胞接着、細胞間相互作用。毛色はagouti。
Colony maintenance
References
Murine tenascin: cDNA cloning, structure and temporal expression of isoforms.
Y Saga, T Tsukamoto, N Jing, M Kusakabe, T Sakakura
Gene, 104, 177-185 (1991). 1717349

Mice develop normally without tenascin.
Y Saga, T Yagi, Y Ikawa, T Sakakura, S Aizawa
Genes Dev., 6, 1821-1831 (1992). 1383086

Can tenascin be redundant in cancer development?
T Sakakura, M Kusakabe
Perspect. Dev. Neurobiol., 2, 111-116 (1994). 7530137

Tenascin knockout mice: barrels, boundary molecules, and glial scars.
D A Steindler, D Settles, H P Erickson, E D Laywell, A Yoshiki, A Faissner, M Kusakabe
J. Neurosci., 15, 1971-1983 (1995). 7534342

Abnormal behavior and neurotransmissions of tenascin gene knockout mouse.
F Fukamauchi, N Mataga, Y J Wang, S Sato, A Youshiki, M Kusakabe
Biochem. Biophys. Res. Commun., 221, 151-156 (1996). 8660327

乳癌基礎研究, 5, 41-45 (1996).

炎症, 15(5), 377-381 (1996).

Tyrosine hydroxylase activity and its mRNA level in dopaminergic neurons of tenascin gene knockout mouse.
F Fukamauchi, N Mataga, Y J Wang, S Sato, A Yoshiki, M Kusakabe
Biochem. Biophys. Res. Commun., 231, 356-359 (1997). 9070278

Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse.
Y Koyama, M Kusubata, A Yoshiki, N Hiraiwa, T Ohashi, S Irie, M Kusakabe
J. Invest. Dermatol., 111, 930-935 (1998). 9856798

Tenascin-C promotes healing of Habu-snake venom-induced glomerulonephritis: studies in knockout congenic mice and in culture.
N Nakao, N Hiraiwa, A Yoshiki, F Ike, M Kusakabe
Am. J. Pathol., 152, 1237-1245 (1998). 9588892
more 5 references
Corneal wound healing in tenascin knockout mouse.
A Matsuda, A Yoshiki, Y Tagawa, H Matsuda, M Kusakabe
Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999). 10235540

乳癌基礎研究, 8, 26-31 (1999).

Loss of cortical and thalamic neuronal tenascin-C expression in a transgenic mouse expressing exon 1 of the human Huntington disease gene.
M Kusakabe, L Mangiarini, E D Laywell, G P Bates, A Yoshiki, N Hiraiwa, J Inoue, D A Steindler
J. Comp. Neurol., 430, 485-500 (2001). 11169482

PDGF receptor-alpha deficiency in glomerular mesangial cells of tenascin-C knockout mice.
Kenji Matsumoto, Noriko Hiraiwa, Atsushi Yoshiki, Masatake Ohnishi, Moriaki Kusakabe
Biochem. Biophys. Res. Commun., 290, 1220-1227 (2002). 11811993

Tenascin-C expression and splice variant in habu snake venom-induced glomerulonephritis.
Kenji Matsumoto, Noriko Hiraiwa, Atsushi Yoshiki, Masatake Ohnishi, Moriaki Kusakabe
Exp. Mol. Pathol., 72, 186-195 (2002). 12009782

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tnc
MGI:101922		tenascin C4Tnc<tm1Sia>
MGI:2148540		targeted mutation 1, Shinichi Aizawa
  • autosomal dominant nonsyndromic hearing loss 56(MedGEN)
    • lacZ beta-galactosidase (E. coli)4
    neo neomycin resistance gene (E. coli)4 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal CNS synaptic transmission (MP:0002206)

  • abnormal circadian behavior (MP:0020467)

  • abnormal serotonin level (MP:0005322)

  • decreased dopamine level (MP:0005643)

  • hearing/vestibular/ear phenotype (MP:0005377)
    • more 3 phenotypes
  • hyperactivity (MP:0001399)

  • impaired swimming (MP:0001522)

  • increased stereotypic behavior (MP:0001409)
    • Detailed phenotype data

    Ordering Information

    供与核酸E. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse tenascin genomic DNA
    Research application
    提供条件研究成果の公表にあたって寄託者の指定する文献を引用する。Am. J. Pathol., 152, 1237-1245 (1998). J. Invest. Dermatol., 111, 930-935 (1998). Invest. Ophthalmol. Vis. Sci., 40, 1071-1080 (1999).
    DepositorRIKEN BRC（独立行政法人理化学研究所）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data