Strain Data Sheet

RBRC00110

update : 2026-01-20

Strain Information
Image
BRC No.	RBRC00110
Type	Targeted Mutation
Species	Mus musculus
Strain name	C3.Cg-Tnc<tm1Sia>/Rbrc
Former Common name	C3H/HeN-TgH(Tnc), C3H-TN, TNKO
H-2 Haplotype
ES Cell line	TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain	C3H/HeNCrlCrlj
Appearance
Strain development
Strain description
Colony maintenance
References	Murine tenascin: cDNA cloning, structure and temporal expression of isoforms. Saga Y, Tsukamoto T, Jing N, Kusakabe M, Sakakura T Gene, 104, 177-185 (1991). 1717349 Mice develop normally without tenascin. Saga Y, Yagi T, Ikawa Y, Sakakura T, Aizawa S Genes Dev., 6, 1821-1831 (1992). 1383086 Can tenascin be redundant in cancer development? Sakakura T, Kusakabe M Perspect. Dev. Neurobiol., 2, 111-116 (1994). 7530137 Tenascin knockout mice: barrels, boundary molecules, and glial scars. Steindler D A, Settles D, Erickson H P, Laywell E D, Yoshiki A, Faissner A, Kusakabe M J. Neurosci., 15, 1971-1983 (1995). 7534342 Abnormal behavior and neurotransmissions of tenascin gene knockout mouse. Fukamauchi F, Mataga N, Wang Y J, Sato S, Youshiki A, Kusakabe M Biochem. Biophys. Res. Commun., 221, 151-156 (1996). 8660327 炎症, 15(5), 377-381 (1996). 乳癌基礎研究, 5, 41-45 (1996). Tyrosine hydroxylase activity and its mRNA level in dopaminergic neurons of tenascin gene knockout mouse. Fukamauchi F, Mataga N, Wang Y J, Sato S, Yoshiki A, Kusakabe M Biochem. Biophys. Res. Commun., 231, 356-359 (1997). 9070278 Tenascin-C promotes healing of Habu-snake venom-induced glomerulonephritis: studies in knockout congenic mice and in culture. Nakao N, Hiraiwa N, Yoshiki A, Ike F, Kusakabe M Am. J. Pathol., 152, 1237-1245 (1998). 9588892 Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse. Koyama Y, Kusubata M, Yoshiki A, Hiraiwa N, Ohashi T, Irie S, Kusakabe M J. Invest. Dermatol., 111, 930-935 (1998). 9856798 more 5 references Corneal wound healing in tenascin knockout mouse. Matsuda A, Yoshiki A, Tagawa Y, Matsuda H, Kusakabe M Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999). 10235540 乳癌基礎研究, 8, 26-31 (1999). Loss of cortical and thalamic neuronal tenascin-C expression in a transgenic mouse expressing exon 1 of the human Huntington disease gene. Kusakabe M, Mangiarini L, Laywell E D, Bates G P, Yoshiki A, Hiraiwa N, Inoue J, Steindler D A J. Comp. Neurol., 430, 485-500 (2001). 11169482 Tenascin-C expression and splice variant in habu snake venom-induced glomerulonephritis. Matsumoto K, Hiraiwa N, Yoshiki A, Ohnishi M, Kusakabe M Exp. Mol. Pathol., 72, 186-195 (2002). 12009782 PDGF receptor-alpha deficiency in glomerular mesangial cells of tenascin-C knockout mice. Matsumoto K, Hiraiwa N, Yoshiki A, Ohnishi M, Kusakabe M Biochem. Biophys. Res. Commun., 290, 1220-1227 (2002). 11811993

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
Tnc MGI:101922	tenascin C	4	Tnc<tm1Sia> MGI:2148540	targeted mutation 1, Shinichi Aizawa			autosomal dominant nonsyndromic hearing loss 56(MedGEN)
lacZ	beta-galactosidase (E. coli)	4
neo	neomycin resistance gene (E. coli)	4				mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype
Phenotype annotation from literatures by Mammalian phenotype ontology	abnormal CNS synaptic transmission (MP:0002206) abnormal circadian behavior (MP:0020467) abnormal serotonin level (MP:0005322) decreased dopamine level (MP:0005643) hearing/vestibular/ear phenotype (MP:0005377) more 3 phenotypes hyperactivity (MP:0001399) impaired swimming (MP:0001522) increased stereotypic behavior (MP:0001409)
Detailed phenotype data

Ordering Information
Donor DNA	E. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse tenascin genomic DNA
Research application
Specific Term and Conditions	In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Am. J. Pathol., 152, 1237-1245 (1998). J. Invest. Dermatol., 111, 930-935 (1998). Invest. Ophthalmol. Vis. Sci., 40, 1071-1080 (1999).
Depositor	RIKEN BRC (RIKEN BRC)
Strain Status	Frozen embryos
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month)
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data