Strain Data Sheet

RBRC00106

Strain Information

Image
BRC No.RBRC00106
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameC3H/HeN-Foxn1<nu>
Former Common nameC3H/HeN-Foxn1<nu>
H-2 Haplotype
ES Cell line
Background strainC3H/HeN
Appearance
Strain development
Strain description
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Foxn1
MGI:102949		forkhead box N111Foxn1<nu>
MGI:1856108		nude
  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy(DisGeNET, MedGEN)

  • T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal Peyer's patch germinal center morphology(MP:0002391)

  • abnormal T cell activation(MP:0001828)

  • abnormal circulating cytokine level(MP:0010210)

  • abnormal circulating gonadotropin level(MP:0003361)

  • abnormal coat/ hair morphology(MP:0000367)
    • more 81 phenotypes
  • abnormal compact bone morphology(MP:0003797)

  • abnormal corneocyte morphology(MP:0030605)

  • abnormal cutaneous collagen fibril morphology(MP:0008438)

  • abnormal embryonic tissue morphology(MP:0002085)

  • abnormal epidermal layer morphology(MP:0001216)

  • abnormal epidermis stratum basale morphology(MP:0001231)

  • abnormal epidermis stratum corneum morphology(MP:0001240)

  • abnormal epidermis stratum granulosum morphology(MP:0001239)

  • abnormal estrous cycle(MP:0001927)

  • abnormal hair cortex keratinization(MP:0009801)

  • abnormal hair cortex morphology(MP:0003811)

  • abnormal hair cuticle(MP:0003810)

  • abnormal hair follicle inner root sheath morphology(MP:0010685)

  • abnormal hair follicle morphology(MP:0000377)

  • abnormal hair shaft morphology(MP:0003809)

  • abnormal liver morphology(MP:0000598)

  • abnormal lymph node T cell domain morphology(MP:0002347)

  • abnormal lymph node morphology(MP:0002339)

  • abnormal muscle morphology(MP:0002108)

  • abnormal nail matrix morphology(MP:0012405)

  • abnormal nail morphology(MP:0000579)

  • abnormal nail plate morphology(MP:0012403)

  • abnormal spleen morphology(MP:0000689)

  • abnormal spleen physiology(MP:0008737)

  • abnormal splenic cell ratio(MP:0008826)

  • abnormal thymus development(MP:0000704)

  • abnormal thymus epithelium morphology(MP:0009544)

  • abnormal thymus morphology(MP:0000703)

  • abnormal trabecular bone morphology(MP:0000130)

  • abnormal venule morphology(MP:0004125)

  • absent vibrissae(MP:0001284)

  • ascites(MP:0005324)

  • asthenozoospermia(MP:0002675)

  • athymia(MP:0000705)

  • blepharitis(MP:0005251)

  • chromosomal instability(MP:0008866)

  • coiled sperm flagellum(MP:0009238)

  • cornea vascularization(MP:0005542)

  • decreased T cell number(MP:0005018)

  • decreased body size(MP:0001265)

  • decreased body weight(MP:0001262)

  • decreased circulating alanine transaminase level(MP:0002942)

  • decreased circulating follicle stimulating hormone level(MP:0002790)

  • decreased circulating interleukin-2 level(MP:0008600)

  • decreased circulating interleukin-6 level(MP:0008597)

  • decreased circulating luteinizing hormone level(MP:0002773)

  • decreased circulating tumor necrosis factor level(MP:0008554)

  • decreased interferon-gamma secretion(MP:0008567)

  • decreased leukocyte cell number(MP:0000221)

  • decreased lymphocyte cell number(MP:0005016)

  • decreased skeletal muscle fiber size(MP:0009400)

  • decreased skeletal muscle mass(MP:0004819)

  • decreased susceptibility to bacterial infection(MP:0002411)

  • decreased susceptibility to parasitic infection(MP:0005026)

  • decreased thymocyte number(MP:0000715)

  • deformed nails(MP:0000580)

  • endocrine/exocrine gland phenotype(MP:0005379)

  • female infertility(MP:0001926)

  • hairless(MP:0003815)

  • impaired spatial learning(MP:0012307)

  • increased bone mineral density(MP:0000062)

  • increased incidence of corneal inflammation(MP:0001313)

  • increased length of allograft survival(MP:0004751)

  • increased plasmacytoma incidence(MP:0010286)

  • increased susceptibility to viral infection induced morbidity/mortality(MP:0009791)

  • increased susceptibility to viral infection(MP:0002418)

  • increased thymocyte apoptosis(MP:0009541)

  • infertility(MP:0001924)

  • nail dystrophy(MP:0012400)

  • postnatal growth retardation(MP:0001732)

  • postnatal lethality, incomplete penetrance(MP:0011086)

  • premature death(MP:0002083)

  • reduced hair shaft melanin granule number(MP:0008732)

  • reduced male fertility(MP:0001922)

  • short nails(MP:0012399)

  • short vibrissae(MP:0001282)

  • small ovary(MP:0001127)

  • small spleen(MP:0000692)

  • small thymus(MP:0000706)

  • thin skin(MP:0001199)

  • wavy vibrissae(MP:0001279)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorTeruyo Sakakura (Houwakai)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data