Strain Data Sheet

RBRC00097

Strain Information

Image
BRC No.RBRC00097
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameC3H-Ttf/t<0>+
Former Common nameC3H-Ttf/t<0>+
H-2 Haplotype
ES Cell line
Background strainC3H/HeN
Appearanceagouti
Strain developmentMaintained by National Institute of Genetics.
Strain descriptionT, Brachyury, semidominant, Chr 17. t, t-complex, recessive, Chr 17. T/T homozygous embryos die at 10 days of gestation due to failure to form a normal mesoderm. T/+ heterozygote have a shortened tail and abnormal sacral vertebrae. T/t mice are tailless. tf/tf homozygous mice show repeated waves of hair loss and regrowth. tf gene is linked to the T/t complex.
Colony maintenanceSibling Mating (T: Heterozygote xHeterozygote; t: Heterozygote x Heterozygote, tf: Heterozygote x Hetrozygote)
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Itpr3
MGI:96624		inositol 1,4,5-triphosphate receptor 317Itpr3<tf>
MGI:1857070		tufted
  • type 1 diabetes mellitus(MedGEN)
    • T
    MGI:98472    		brachyury, T-box transcription factor T17T
    MGI:1856184    		brachyury
  • neural tube defect(MedGEN)

  • sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome(MedGEN)
    • t
    MGI:105076    		t-complex17t<0>
    MGI:1856730    		t, 0

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal allogrooming behavior(MP:0011000)

  • abnormal brain commissure morphology(MP:0002199)

  • abnormal cerebral cortex morphology(MP:0000788)

  • abnormal coat/ hair morphology(MP:0000367)

  • abnormal dorsal aorta morphology(MP:0004787)
    • more 68 phenotypes
  • abnormal epidermal layer morphology(MP:0001216)

  • abnormal forelimb bud morphology(MP:0013164)

  • abnormal gustatory system physiology(MP:0001985)

  • abnormal hair cycle(MP:0000427)

  • abnormal hair growth(MP:0002073)

  • abnormal head shape(MP:0011495)

  • abnormal heart looping(MP:0000269)

  • abnormal heart tube morphology(MP:0000270)

  • abnormal limb bud morphology(MP:0005650)

  • abnormal liquid preference(MP:0001423)

  • abnormal locomotor activation(MP:0003313)

  • abnormal lumbar vertebrae morphology(MP:0003049)

  • abnormal neocortex morphology(MP:0008547)

  • abnormal nervous system development(MP:0003861)

  • abnormal neural tube morphology(MP:0002151)

  • abnormal notochord morphology(MP:0002825)

  • abnormal pericardial cavity morphology(MP:0012501)

  • abnormal placenta development(MP:0001712)

  • abnormal primitive streak formation(MP:0002230)

  • abnormal rostral-caudal body axis extension(MP:0003885)

  • abnormal social investigation(MP:0001360)

  • abnormal somite development(MP:0001688)

  • abnormal spinal cord morphology(MP:0000955)

  • abnormal tail bud morphology(MP:0002861)

  • abnormal tail development(MP:0006281)

  • abnormal tail morphology(MP:0002111)

  • abnormal thoracic vertebrae morphology(MP:0003047)

  • abnormal vertebrae morphology(MP:0000137)

  • abnormal vocalization(MP:0001529)

  • absent caudal vertebrae(MP:0004653)

  • absent corpus callosum(MP:0002196)

  • absent hindlimb buds(MP:0013168)

  • absent notochord(MP:0000932)

  • absent sacral vertebrae(MP:0004656)

  • absent tail(MP:0003456)

  • absent vertebrae(MP:0000138)

  • absent vertebral arch(MP:0004603)

  • absent vertebral body(MP:0004668)

  • bleb(MP:0008854)

  • caudal body truncation(MP:0004073)

  • decreased anterior commissure size(MP:0008226)

  • decreased anxiety-related response(MP:0001364)

  • decreased caudal vertebrae number(MP:0001539)

  • decreased embryo size(MP:0001698)

  • decreased hippocampal commissure size(MP:0008222)

  • decreased presacral vertebrae number(MP:0000461)

  • decreased survivor rate(MP:0008770)

  • decreased ventral ectodermal ridge size(MP:0012714)

  • delayed heart development(MP:0012082)

  • embryonic lethality during organogenesis, complete penetrance(MP:0011098)

  • excessive vocalization(MP:0013140)

  • hemopericardium(MP:0005244)

  • hemorrhage(MP:0001914)

  • impaired social transmission of food preference(MP:0002969)

  • increased body weight(MP:0001260)

  • increased fluid intake(MP:0011941)

  • increased grooming behavior(MP:0001441)

  • increased growth rate(MP:0002865)

  • kinked neural tube(MP:0003400)

  • low sweet preference(MP:0012347)

  • male infertility(MP:0001925)

  • meningomyelocele(MP:0009929)

  • notochord degeneration(MP:0004712)

  • perinatal lethality, incomplete penetrance(MP:0011090)

  • short tail(MP:0000592)

  • sparse hair(MP:0000416)

  • split notochord(MP:0004713)

  • transmission ratio distortion(MP:0004179)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorToshihiko Shiroishi (National Institute of Genetics)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data