Strain Data Sheet

RBRC00073

Strain Information

Image
BRC No.RBRC00073
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameBUS/Idr-bus
Former Common nameBUS/Idr-bus
H-2 Haplotype
ES Cell line
Background strainKYF
Appearancebrown agouti [A/A b/b C/C]
Strain development愛知県心身障害者コロニー発達障害研究所・米澤　敏先生。KYF/MsIdr-Jsr系統に生じた自然突然変異。
Strain descriptionCdh23遺伝子に生じたbus突然変異。ホモマウスは内耳有毛神経細胞変性を起こす。旋回、頭振の行動異常、内耳性難聴を呈する。ホモ雌は繁殖が可能なものの、育仔は困難。bus系統 (RBRC00073) 、コントロール (正常) 系統 (RBRC00072) 。
Colony maintenanceHeterozygote (female) x Homozygote (male) [or Crossing to BUS/Idr-+/+(RBRC00072)]
ReferencesHuman Mutation, 27, 88-97 (2006). 16281288
Acta Otolaryngol. (Stockh), 116, 409-416 (1996). 8790740
Acta Otolaryngol., 117, 20-24 (1997). 9039475
Acta Otolaryngol. Suppl., 519, 286-293 (1995). 7610888
Hear. Res., 134, 116-122 (1999). 10452381

Health Report

Examination Date / Room / Rack2024/02/26Room:4-BRack:K
2023/11/27Room:4-BRack:K
2023/08/28Room:4-BRack:K
2023/05/29Room:4-BRack:K
2023/02/27Room:4-BRack:K
2022/11/29Room:4-BRack:K
2022/08/29Room:4-BRack:K
2022/05/31Room:4-BRack:K

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Cdh23cadherin 23 (otocadherin)10Cdh23<v-bus>bustling4930542A03Rik, ahl, ahl1, bob, mdfw, nmf112, nmf181, nmf252, USH1D

Ordering Information

供与核酸
Research applicationNeurobiology Research
Sensorineural Research
提供条件条件を付加しない。
Depositor米澤　敏（愛知県心身障害者コロニー発達障害研究所）
Strain Status生体のアイコン生体
凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
生体マウスを3~6ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data