Strain Data Sheet

RBRC00066

Strain Information

Image
BRC No.RBRC00066
TypeTargeted Mutation and Spontaneous MutationCartagena
SpeciesMus musculus
Strain nameC.Cg-Tnc<tm1Sia> Reln<rl-Orl>/Rbrc
Former Common nameBALB/c-Reln<rl>/+ -TgH(Tnc), TN-reeler, BALB/cA-Reln<rl-Orl>/+ -TgH(Tnc)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainBALB/cA
Appearance
Strain development
Strain description
Colony maintenance
References
Murine tenascin: cDNA cloning, structure and temporal expression of isoforms.
Saga Y, Tsukamoto T, Jing N, Kusakabe M, Sakakura T
Gene, 104, 177-185 (1991). 1717349

Mice develop normally without tenascin.
Saga Y, Yagi T, Ikawa Y, Sakakura T, Aizawa S
Genes Dev., 6, 1821-1831 (1992). 1383086

Tenascin knockout mice: barrels, boundary molecules, and glial scars.
Steindler D A, Settles D, Erickson H P, Laywell E D, Yoshiki A, Faissner A, Kusakabe M
J. Neurosci., 15, 1971-1983 (1995). 7534342

The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons.
Hirotsune S, Takahara T, Sasaki N, Hirose K, Yoshiki A, Ohashi T, Kusakabe M, Murakami Y, Muramatsu M, Watanabe S, et a l
Nat. Genet., 10, 77-83 (1995). 7647795

Abnormal behavior and neurotransmissions of tenascin gene knockout mouse.
Fukamauchi F, Mataga N, Wang Y J, Sato S, Youshiki A, Kusakabe M
Biochem. Biophys. Res. Commun., 221, 151-156 (1996). 8660327

Dysfunction of the Orleans reeler gene arising from exon skipping due to transposition of a full-length copy of an active L1 sequence into the skipped exon.
Takahara T, Ohsumi T, Kuromitsu J, Shibata K, Sasaki N, Okazaki Y, Shibata H, Sato S, Yoshiki A, Kusakabe M, Muramatsu M, Ueki M, Okuda K, Hayashizaki Y
Hum. Mol. Genet., 5, 989-993 (1996). 8817336

Tyrosine hydroxylase activity and its mRNA level in dopaminergic neurons of tenascin gene knockout mouse.
Fukamauchi F, Mataga N, Wang Y J, Sato S, Yoshiki A, Kusakabe M
Biochem. Biophys. Res. Commun., 231, 356-359 (1997). 9070278

Cerebellar histogenesis as seen in identified cells of normal-reeler mouse chimeras.
Yoshiki A, Kusakabe M
Int. J. Dev. Biol., 42, 695-700 (1998). 9712524

Loss of cortical and thalamic neuronal tenascin-C expression in a transgenic mouse expressing exon 1 of the human Huntington disease gene.
Kusakabe M, Mangiarini L, Laywell E D, Bates G P, Yoshiki A, Hiraiwa N, Inoue J, Steindler D A
J. Comp. Neurol., 430, 485-500 (2001). 11169482

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tnc
MGI:101922		tenascin C4Tnc<tm1Sia>
MGI:2148540		targeted mutation 1, Shinichi Aizawa
  • autosomal dominant nonsyndromic hearing loss 56(MedGEN)
    • lacZ beta-galactosidase (E. coli)4
    neo neomycin resistance gene (E. coli)4 mouse phosphoglycerate kinase promoter (PGK promoter)
    Reln
    MGI:103022    		reelin5Reln<rl-Orl>
    MGI:1856416    		reeler Orleans
  • epilepsy, familial temporal lobe, 1(MedGEN)

  • familial temporal lobe epilepsy 7(MedGEN)

  • Norman-Roberts syndrome(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal CNS synaptic transmission(MP:0002206)

  • abnormal circadian behavior(MP:0020467)

  • abnormal olfactory bulb granule cell layer morphology(MP:0009949)

  • abnormal olfactory bulb morphology(MP:0000819)

  • abnormal postnatal subventricular zone morphology(MP:0004275)
    • more 7 phenotypes
  • abnormal rostral migratory stream morphology(MP:0004279)

  • abnormal serotonin level(MP:0005322)

  • decreased dopamine level(MP:0005643)

  • hyperactivity(MP:0001399)

  • impaired swimming(MP:0001522)

  • increased stereotypic behavior(MP:0001409)

  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse tenascin genomic DNA
    Research applicationMouse Models for Human Disease
    Neurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 5, 989-993 (1996). Biochem. Biophys. Res. Commun., 221, 151-156 (1996). J. Neuroscience, 15, 1971-1983 (1995).
    DepositorRIKEN BRC (RIKEN BRC)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data