Strain Data Sheet

RBRC00047

Strain Information

Image
BRC No.RBRC00047
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6C3Fe a/a-Kit<W-Rbrc2>/Rbrc
Former Common nameB6C3Fe-a/a-WR2; B6C3Fe-a/a-W<R2>
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack, white spotting [a/a W/+]
white with black eyes [a/a W/W]
Strain developmentSpontaneous mutation arosed in B6C3Fe-a/a-pcd at the RIKEN BRC.
Strain descriptionB6C3Fe a/a-Kit<W-Rbrc2>/Rbrc. Spontaneous mutation arosed in B6C3Fe-a/a-pcd. Heterozygous mutant mice are black, white spotting. Homozygous mice are white with black eyes, and sterile. This strain is useful for the study of Kit gene function.
Colony maintenanceSibling Mating (Heterozygote x Wild-type, Heterozygote)
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Agtpbp1
MGI:2159437		ATP/GTP binding protein 113Agtpbp1<pcd> Purkinje cell degeneration
  • neurodegeneration, childhood-onset, with cerebellar atrophy(MedGEN)
    • a
    MGI:87853    		nonagouti2a<a>
    MGI:1855937    		nonagouti
    Kit
    MGI:96677    		KIT proto-oncogene receptor tyrosine kinase5Kit<W-2Rbrc> RIKEN BRC 2
  • acute myeloid leukemia(DisGeNET, MedGEN)

  • cutaneous mastocytosis(MedGEN)

  • gastrointestinal stromal tumor(DisGeNET, MedGEN)
    • more 3 Diseases
  • mastocytosis(DisGeNET)

  • piebaldism(DisGeNET, MedGEN)

  • testicular germ cell tumor(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • belly spot(MP:0000373)

  • infertility(MP:0001924)

  • variable body spotting(MP:0002940)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorRIKEN BRC (RIKEN BRC)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data