Strain Data Sheet

RBRC00045

Strain Information

Image
BRC No.RBRC00045
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6C3Fe-a/a-Reln<rl>
Former Common name
H-2 Haplotype
ES Cell line
Background strainmixed background of B6 and C3H.
Appearanceblack, ataxic [a/a Relnrl/Relnrl]
black, unaffected [a/a +/? or a/a Relnrl/+]
Strain developmentThis substrain of reeler mice were developed by Ogawa M (Neuron14, 1995) by extensive selection ofhomozygous breeders from original mutant mice. The strain has been maintained by sister brother mating for more than15 generations in RIKEN Tsukuba Institute.
Strain descriptionThe reeler mutation was first identified by Falconer as neurological mutant mice with abnormal locomotion (J Genet 50, 192-201, 1951) . Laminar formation of cerebral and cerebellar cortex was severely impaired in homozygous mutant mice. This mutant lacks entire Relin gene associated with large deletion of about 150kb.
Colony maintenanceHeterozygous females x homozygous males, or heterozygote x heterozygote. Some homozygous females may also be used as breeders.
ReferencesDevelopment, 128, 1983-1993 (2001). 11493521
Nat. Genet., 26, 93-96 (2000). 10973257
Proc. Natl. Acad. Sci. USA, 97, 8612-8616 (2000). 10880573
Neuron, 31, 929-941 (2001). 11580894
Neuron, 14, 899-912 (1995). 7748558
Nat. Genet., 10, 77-83 (1995). 7647795
Proc. Natl. Acad. Sci. USA, 98, 3477-3482 (2001). 11248103

Health Report

Examination Date / Room / Rack2024/02/26Room:4-BRack:G
2023/11/27Room:4-BRack:G
2023/08/28Room:4-BRack:G
2023/05/29Room:4-BRack:G
2023/02/27Room:4-BRack:G

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
anonagouti2a<a>nonagouti

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Relnreelin5Reln<rl>reeler

Ordering Information

供与核酸
Research applicationDevelopmental Biology Research
Mouse Models for Human Disease
Neurobiology Research
提供条件条件を付加しない。
Depositor小川　正晴（理化学研究所脳科学総合研究センター）
Strain Status生体のアイコン生体
凍結胚のアイコン凍結胚
Strain Availability凍結胚を1ヶ月以内に提供可能
生体マウスを3~6ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data