RBRC00045

Information1

Image
BRC No.RBRC00045
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6C3Fe-a/a-Relnrl
Former Common name
H-2 Haplotype
ES Cell line
Background strainmixed background of B6 and C3H.
Appearanceblack, unaffected [a/a +/? or a/a Relnrl/+]
black, ataxic [a/a Relnrl/Relnrl]
Strain developmentThis substrain of reeler mice were developed by Ogawa M (Neuron14, 1995) by extensive selection ofhomozygous breeders from original mutant mice. The strain has been maintained by sister brother mating for more than15 generations in RIKEN Tsukuba Institute.
Strain descriptionThe reeler mutation was first identified by Falconer as neurological mutant mice with abnormal locomotion (J Genet 50, 192-201, 1951) . Laminar formation of cerebral and cerebellar cortex was severely impaired in homozygous mutant mice. This mutant lacks entire Relin gene associated with large deletion of about 150kb.
Colony maintenanceHeterozygous females x homozygous males, or heterozygote x heterozygote. Some homozygous females may also be used as breeders.
ReferencesProc. Natl. Acad. Sci. USA, 98, 3477-3482 (2001). 11248103
Proc. Natl. Acad. Sci. USA, 97, 8612-8616 (2000). 10880573
Nat. Genet., 10, 77-83 (1995). 7647795
Nat. Genet., 26, 93-96 (2000). 10973257
Neuron, 31, 929-941 (2001). 11580894
Development, 128, 1983-1993 (2001). 11493521
Neuron, 14, 899-912 (1995). 7748558

Health Report

Examination Date / Room / Rack2016/03/07Room:2-3Rack:B
2016/01/12Room:2-3Rack:B
2015/11/09Room:2-3Rack:B
2015/09/07Room:2-3Rack:B

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Relnreelin5Reln<rl>reeler

Information2

Donor DNA
Research applicationDevelopmental Biology Research
Mouse Models for Human Disease
Neurobiology Research
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorMasaharu Ogawa (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data