Strain Information | |
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Image | |
BRC No. | RBRC00045 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | B6C3Fe-a/a-Reln<rl> |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | mixed background of B6 and C3H. |
Appearance | black, unaffected [a/a +/? or a/a Relnrl/+] black, ataxic [a/a Relnrl/Relnrl] |
Strain development | This substrain of reeler mice were developed by Ogawa M (Neuron14, 1995) by extensive selection ofhomozygous breeders from original mutant mice. The strain has been maintained by sister brother mating for more than15 generations in RIKEN Tsukuba Institute. |
Strain description | The reeler mutation was first identified by Falconer as neurological mutant mice with abnormal locomotion (J Genet 50, 192-201, 1951) . Laminar formation of cerebral and cerebellar cortex was severely impaired in homozygous mutant mice. This mutant lacks entire Relin gene associated with large deletion of about 150kb. |
Colony maintenance | Heterozygous females x homozygous males, or heterozygote x heterozygote. Some homozygous females may also be used as breeders. |
References | The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons. Hirotsune S, Takahara T, Sasaki N, Hirose K, Yoshiki A, Ohashi T, Kusakabe M, Murakami Y, Muramatsu M, Watanabe S, et a l Nat. Genet., 10, 77-83 (1995). 7647795Reelin controls position of autonomic neurons in the spinal cord. Yip J W, Yip Y P, Nakajima K, Capriotti C Proc. Natl. Acad. Sci. USA, 97, 8612-8616 (2000). 10880573The reelin pathway modulates the structure and function of retinal synaptic circuitry. Rice D S, Nusinowitz S, Azimi A M, Martinez A, Soriano E, Curran T Neuron, 31, 929-941 (2001). 11580894The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Ogawa M, Miyata T, Nakajima K, Yagyu K, Seike M, Ikenaka K, Yamamoto H, Mikoshiba K Neuron, 14, 899-912 (1995). 7748558Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Hong S E, Shugart Y Y, Huang D T, Shahwan S A, Grant P E, Hourihane J O, Martin N D, Walsh C A Nat. Genet., 26, 93-96 (2000). 10973257Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression. Tarabykin V, Stoykova A, Usman N, Gruss P Development, 128, 1983-1993 (2001). 11493521Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse. Liu W S, Pesold C, Rodriguez M A, Carboni G, Auta J, Lacor P, Larson J, Condie B G, Guidotti A, Costa E Proc. Natl. Acad. Sci. USA, 98, 3477-3482 (2001). 11248103 |
Health Report | |
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Examination Date / Room / Rack | 2024/08/26Room:4-BRack:G 2024/05/27Room:4-BRack:G 2024/02/26Room:4-BRack:G 2023/11/27Room:4-BRack:G 2023/08/28Room:4-BRack:G 2023/05/29Room:4-BRack:G 2023/02/27Room:4-BRack:G |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
a | nonagouti | 2 | a | nonagouti | |||
Reln | reelin | 5 | Reln | reeler |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 37 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | Developmental Biology Research Mouse Models for Human Disease Neurobiology Research |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | Masaharu Ogawa (RIKEN) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |