Strain Information | |
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Image | |
BRC No. | RBRC00040 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | C;B6 a-Kit<W-sh>/Rbrc |
Former Common name | C;B6-a/a・B/B-W Sh/+, Sash black, B6C3-W Sh/+ (black) |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | white spot [Sh hetero] black eyed, white coat, affected [Sh homo] |
Strain development | C57BL/6-WSh/+ was gifted from Dr. Yukihiko Kitamura, Osaka University to Dr. Kusakabe M, RIKEN Tsukuba Institute. |
Strain description | Homozygotes are viable, males are sterile. Sash semidominannt |
Colony maintenance | |
References | Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo. Grimbaldeston M A, Chen C C, Piliponsky A M, Tsai M, Tam S Y, Galli S J Am. J. Pathol., 167, 835-848 (2005) 16127161C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice: age-dependent abolishment of c-kit gene expression. Yamazaki M, Tsujimura T, Morii E, Isozaki K, Onoue H, Nomura S, Kitamura Y Blood, 83, 3509-3516 (1994). 7515715W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis. Duttlinger R, Manova K, Chu T Y, Gyssler C, Zelenetz A D, Bachvarova R F, Besmer P Development, 118, 705-717 (1993). 7521281The W(sh), W(57), and Ph Kit expression mutations define tissue-specific control elements located between -23 and -154 kb upstream of Kit. Berrozpe G, Timokhina I, Yukl S, Tajima Y, Ono M, Zelenetz A D, Besmer P Blood, 94, 2658-2666 (1999). 10515869c-kit Gene was not transcribed in cultured mast cells of mast cell-deficient Wsh/Wsh mice that have a normal number of erythrocytes and a normal c-kit coding region. Tono T, Tsujimura T, Koshimizu U, Kasugai T, Adachi S, Isozaki K, Nishikawa S, Morimoto M, Nishimune Y, Nomura S, et a l Blood, 15, 1448-1453 (1992). 1381627 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
a | nonagouti | 2 | a | nonagouti | |||
Kit | KIT proto-oncogene receptor tyrosine kinase | 5 | Kit | sash |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 8 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | Developmental Biology Research |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | RIKEN BRC (RIKEN BRC) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |