Strain Data Sheet

RBRC00012

Strain Information

Image
BRC No.RBRC00012
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameAKR/Ms-Rb(6.15)-Foxn1<nu>
Former Common nameAKR/Ms-Rb(6.15)-Foxn1<nu>
H-2 Haplotype
ES Cell line
Background strainAKR
Appearancealbino, hairless albino [nu/+, Rb]
Strain development
Strain descriptionimmunodefecient, nude
Colony maintenance
References
Trisomy of chromosome 6.15 is not necessary for proliferation of AKR(Rb6.15)1Ald lymphoma cells.
S S Boggs, K D Patrene, W R Downer, G N Schwartz, D F Saxe
Cancer Genet. Cytogenet., 9, 151-166 (1983). 6850555

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Foxn1
MGI:102949		forkhead box N111Foxn1<nu>
MGI:1856108		nude
  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy(DisGeNET, MedGEN)

  • T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant(MedGEN)
    • Rb(6.15)1Ald
    MGI:103904    		Robertsonian translocation, Chr 6 and 15, Leonard 115Rb(6.15)1Ald
    Rb(6.15)1Ald
    MGI:103903    		Robertsonian translocation, Chr 6 and 15, Leonard 16Rb(6.15)1Ald

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal Peyer's patch germinal center morphology (MP:0002391)

  • abnormal T cell activation (MP:0001828)

  • abnormal circulating cytokine level (MP:0010210)

  • abnormal circulating gonadotropin level (MP:0003361)

  • abnormal coat/ hair morphology (MP:0000367)
    • more 77 phenotypes
  • abnormal compact bone morphology (MP:0003797)

  • abnormal corneocyte morphology (MP:0030605)

  • abnormal cutaneous collagen fibril morphology (MP:0008438)

  • abnormal embryonic tissue morphology (MP:0002085)

  • abnormal epidermal layer morphology (MP:0001216)

  • abnormal epidermis stratum basale morphology (MP:0001231)

  • abnormal epidermis stratum corneum morphology (MP:0001240)

  • abnormal epidermis stratum granulosum morphology (MP:0001239)

  • abnormal estrous cycle (MP:0001927)

  • abnormal hair cortex keratinization (MP:0009801)

  • abnormal hair cortex morphology (MP:0003811)

  • abnormal hair cuticle (MP:0003810)

  • abnormal hair follicle inner root sheath morphology (MP:0010685)

  • abnormal hair follicle morphology (MP:0000377)

  • abnormal hair shaft morphology (MP:0003809)

  • abnormal liver morphology (MP:0000598)

  • abnormal lymph node T cell domain morphology (MP:0002347)

  • abnormal lymph node morphology (MP:0002339)

  • abnormal muscle morphology (MP:0002108)

  • abnormal nail matrix morphology (MP:0012405)

  • abnormal nail morphology (MP:0000579)

  • abnormal nail plate morphology (MP:0012403)

  • abnormal spleen morphology (MP:0000689)

  • abnormal spleen physiology (MP:0008737)

  • abnormal splenic cell ratio (MP:0008826)

  • abnormal thymus development (MP:0000704)

  • abnormal thymus morphology (MP:0000703)

  • abnormal trabecular bone morphology (MP:0000130)

  • abnormal venule morphology (MP:0004125)

  • absent vibrissae (MP:0001284)

  • ascites (MP:0005324)

  • asthenozoospermia (MP:0002675)

  • athymia (MP:0000705)

  • blepharitis (MP:0005251)

  • chromosomal instability (MP:0008866)

  • coiled sperm flagellum (MP:0009238)

  • cornea vascularization (MP:0005542)

  • decreased T cell number (MP:0005018)

  • decreased body size (MP:0001265)

  • decreased body weight (MP:0001262)

  • decreased circulating alanine transaminase level (MP:0002942)

  • decreased circulating follicle stimulating hormone level (MP:0002790)

  • decreased circulating interleukin-2 level (MP:0008600)

  • decreased circulating interleukin-6 level (MP:0008597)

  • decreased circulating luteinizing hormone level (MP:0002773)

  • decreased circulating tumor necrosis factor level (MP:0008554)

  • decreased interferon-gamma secretion (MP:0008567)

  • decreased leukocyte cell number (MP:0000221)

  • decreased lymphocyte cell number (MP:0005016)

  • decreased skeletal muscle fiber size (MP:0009400)

  • decreased skeletal muscle mass (MP:0004819)

  • decreased susceptibility to bacterial infection (MP:0002411)

  • decreased susceptibility to parasitic infection (MP:0005026)

  • deformed nails (MP:0000580)

  • endocrine/exocrine gland phenotype (MP:0005379)

  • female infertility (MP:0001926)

  • hairless (MP:0003815)

  • impaired spatial learning (MP:0012307)

  • increased bone mineral density (MP:0000062)

  • increased incidence of corneal inflammation (MP:0001313)

  • increased length of allograft survival (MP:0004751)

  • increased plasmacytoma incidence (MP:0010286)

  • increased susceptibility to viral infection (MP:0002418)

  • increased susceptibility to viral infection induced morbidity/mortality (MP:0009791)

  • nail dystrophy (MP:0012400)

  • postnatal growth retardation (MP:0001732)

  • postnatal lethality, incomplete penetrance (MP:0011086)

  • premature death (MP:0002083)

  • reduced hair shaft melanin granule number (MP:0008732)

  • reduced male fertility (MP:0001922)

  • short nails (MP:0012399)

  • short vibrissae (MP:0001282)

  • small ovary (MP:0001127)

  • small spleen (MP:0000692)

  • small thymus (MP:0000706)

  • thin skin (MP:0001199)

  • wavy vibrissae (MP:0001279)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationCancer Research
    提供条件条件を付加しない。
    Depositor志佐　湍（埼玉県立がんセンター研究所）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data