Strain Data Sheet

RBRC00005

Strain Information

Image
BRC No.RBRC00005
TypeCongenic
SpeciesMus musculus
Strain nameA.Cg-H2-T18<b>/Rbrc
Former Common nameA-Tlab
H-2 Haplotype
ES Cell line
Background strainA
Appearancealbino
Strain developmentMaintained by Toshitada Takahashi, Aichi Cancer Center Research Institute.
Strain descriptionMajor Histocompatibility complex (H2) congenic strain having a H2-T18<b> haplotype.
Colony maintenanceHomozygote x Homozygote
References
J. Natl. Cancer Inst., 31, 977-995 (1963).

Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex.
Y Obata, Y Satta, K Moriwaki, T Shiroishi, H Hasegawa, T Takahashi, N Takahata
Proc. Natl. Acad. Sci. USA, 91, 6589-6593 (1994). 8022824

Genetics in Wild Mice, 159-177 (1994). ISBN4762277746

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
H2-T18
MGI:95950		histocompatibility 2, T region locus 1817H2-T18<b> b variant

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal CD8 positive, alpha-beta intraepithelial T cell morphology (MP:0008401)

  • abnormal CD8-positive, gamma-delta intraepithelial T cell morphology (MP:0008361)

  • abnormal intraepithelial T cell morphology (MP:0008894)

  • abnormal intraepithelial T cell number (MP:0008895)

  • colitis (MP:0002816)
    • more 5 phenotypes
  • enlarged mesenteric lymph nodes (MP:0008466)

  • increased interferon-gamma secretion (MP:0008566)

  • increased interleukin-4 secretion (MP:0008699)

  • intestinal inflammation (MP:0001858)

  • premature death (MP:0002083)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationCancer Research
    Immunology and Inflammation Research
    提供条件条件を付加しない。
    Depositor高橋　利忠（愛知県がんセンター）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data