Strain Data Sheet

RBRC-GSC0036

Strain Information

Image
BRC No.RBRC-GSC0036
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameM100174
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain descriptionHyperactivity in open-field (6.0 to 12.4 SDs above the mean). Hyperactivity in home-cage. Deficit in passive avoidance response.
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal behavioral response to xenobiotic(MP:0009745)

  • abnormal neuron physiology(MP:0004811)

  • abnormal physiological response to xenobiotic(MP:0008872)

  • abnormal social investigation(MP:0001360)

  • behavior/neurological phenotype(MP:0005386)
  • more 5 phenotypes
  • hyperactivity(MP:0001399)

  • impaired passive avoidance behavior(MP:0004000)

  • increased exploration in new environment(MP:0001415)

  • perinatal lethality, incomplete penetrance(MP:0011090)

  • postnatal lethality, incomplete penetrance(MP:0011086)
  • Detailed phenotype dataPhenopub Link

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of for-profit institution must contact the DEPOSITOR separately.
    The RECIPIENT of not for-profit institution must contact and discuss in good faith with the DEPOSITOR regarding inventorship, ownership, patent filing and licese fees and others, prior to filing a patent or make a contract with license fees with a third party for invention or products obtained from research results by using the BIOLOGICAL RESOURCES.
    DepositorRIKEN GSC (RIKEN GSC)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Mouse of the Month Jun 2010

    BRC mice in Publications

    Umemori J, Takao K, Koshimizu H, Hattori S, Furuse T, Wakana S, Miyakawa T.
    ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response.
    BMC Res Notes 6 203(2013) 23688147
    Furuse T, Wada Y, Hattori K, Yamada I, Kushida T, Shibukawa Y, Masuya H, Kaneda H, Miura I, Seno N, Kanda T, Hirose R, Toki S, Nakanishi K, Kobayashi K, Sezutsu H, Gondo Y, Noda T, Yuasa S, Wakana S.
    Phenotypic characterization of a new Grin1 mutant mouse generated by ENU mutagenesis.
    Eur J Neurosci 31(7) 1281-91(2010) 20345915