Strain Data Sheet

RBRC-GD000099

Strain Information

Image
BRC No.RBRC-GD000099
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameSrr<Rgsc01872>
Former Common nameM101872
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by the Functional Genomics Research Group at RIKEN Genomic Sciences Center (Biochem Biophys Res Commun. 2005 336: 609-16.) (Now Mutagenesis and Genomics Team, RIKEN BioResource Center) .
Strain descriptionMutant mouse strain established by RIKEN ENU-based gene-driven mutagenesis. Gene: Srr, Substitution: T→A, Type: Tyr > stop, Schizophrenia-like syndrome, Labrie et al. (2009) Hum Mol Genet 18(17): 3227-3243.
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Srrserine racemase11Srr

Ordering Information

供与核酸
Research application
提供条件条件を付加する。
営利機関の利用者は、別途寄託者に連絡する。
非営利機関の利用者は、本件リソースを利用して研究過程において得られた発明及び成果物について特許申請及び第三者と使用料ライセンス契約を行う場合、利用者は事前に理研ＢＲＣに連絡の上、両者で、発明者、所有権、特許出願、ライセンス料等の取扱いについて、実施に先立って協議するものとする。
Depositor権藤　洋一（RIKEN GSC）
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結精子より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Zhang H, Kuang XL, Chang Y, Lu J, Jiang H, Wu S.
Reduced serine racemase expression in aging rat cerebellum is associated with oxidative DNA stress and hypermethylation in the promoter.
Brain Res 1629 221-30(2015) 26505919

Jiang H, Du J, Song J, Li Y, Wu M, Zhou J, Wu S.
Loss-of-function mutation of serine racemase attenuates retinal ganglion cell loss in diabetic mice.
Exp Eye Res 175 90-97(2018) 29913163

Labrie V, Fukumura R, Rastogi A, Fick LJ, Wang W, Boutros PC, Kennedy JL, Semeralul MO, Lee FH, Baker GB, Belsham DD, Barger SW, Gondo Y, Wong AH, Roder JC.
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.
Hum Mol Genet 18(17) 3227-43(2009) 19483194

Jiang H, Wu M, Liu Y, Song L, Li S, Wang X, Zhang YF, Fang J, Wu S.
Serine racemase deficiency attenuates choroidal neovascularization and reduces nitric oxide and VEGF levels by retinal pigment epithelial cells.
J Neurochem 143(3) 375-388(2017) 28892569

Jiang H, Wang X, Zhang H, Chang Y, Feng M, Wu S.
Loss-of-function mutation of serine racemase attenuates excitotoxicity by intravitreal injection of N-methyl-D-aspartate.
J Neurochem 136(1) 186-93(2016) 26485193

Zhang H, Song L, Chang Y, Wu M, Kuang X, Jiang H, Wu S.
Potential deficit from decreased cerebellar granule cell migration in serine racemase-deficient mice is reversed by increased expression of GluN2B and elevated levels of NMDAR agonists.
Mol Cell Neurosci 85 119-126(2017) 28939329