Strain Data Sheet

RBRC-GD000099

Strain Information

Image
BRC No.RBRC-GD000099
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameSrr<Rgsc01872>
Former Common nameM101872
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by the Functional Genomics Research Group at RIKEN Genomic Sciences Center (Biochem Biophys Res Commun. 2005 336: 609-16.) (Now Mutagenesis and Genomics Team, RIKEN BioResource Center) .
Strain descriptionMutant mouse strain established by RIKEN ENU-based gene-driven mutagenesis. Gene: Srr, Substitution: T→A, Type: Tyr > stop, Schizophrenia-like syndrome, Labrie et al. (2009) Hum Mol Genet 18(17): 3227-3243.
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Srr
MGI:1351636		serine racemase11Srr

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal long-term spatial reference memory(MP:0008432)

  • abnormal social investigation(MP:0001360)

  • abnormal spatial reference memory(MP:0008414)

  • decreased prepulse inhibition(MP:0009142)

  • decreased serine level(MP:0030692)
    • more 2 phenotypes
  • increased serine level(MP:0030691)

  • induced hyperactivity(MP:0008911)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of for-profit institution must contact the DEPOSITOR separately.
    The RECIPIENT of not for-profit institution must contact and discuss in good faith with the DEPOSITOR regarding inventorship, ownership, patent filing and licese fees and others, prior to filing a patent or make a contract with license fees with a third party for invention or products obtained from research results by using the BIOLOGICAL RESOURCES.
    DepositorYoichi Gondo (RIKEN GSC)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Jiang H, Du J, Song J, Li Y, Wu M, Zhou J, Wu S.
    Loss-of-function mutation of serine racemase attenuates retinal ganglion cell loss in diabetic mice.
    Exp Eye Res 175 90-97(2018) 29913163
    Jiang H, Wu M, Liu Y, Song L, Li S, Wang X, Zhang YF, Fang J, Wu S.
    Serine racemase deficiency attenuates choroidal neovascularization and reduces nitric oxide and VEGF levels by retinal pigment epithelial cells.
    J Neurochem 143(3) 375-388(2017) 28892569
    Zhang H, Song L, Chang Y, Wu M, Kuang X, Jiang H, Wu S.
    Potential deficit from decreased cerebellar granule cell migration in serine racemase-deficient mice is reversed by increased expression of GluN2B and elevated levels of NMDAR agonists.
    Mol Cell Neurosci 85 119-126(2017) 28939329
    Jiang H, Wang X, Zhang H, Chang Y, Feng M, Wu S.
    Loss-of-function mutation of serine racemase attenuates excitotoxicity by intravitreal injection of N-methyl-D-aspartate.
    J Neurochem 136(1) 186-93(2016) 26485193
    Zhang H, Kuang XL, Chang Y, Lu J, Jiang H, Wu S.
    Reduced serine racemase expression in aging rat cerebellum is associated with oxidative DNA stress and hypermethylation in the promoter.
    Brain Res 1629 221-30(2015) 26505919
    Labrie V, Fukumura R, Rastogi A, Fick LJ, Wang W, Boutros PC, Kennedy JL, Semeralul MO, Lee FH, Baker GB, Belsham DD, Barger SW, Gondo Y, Wong AH, Roder JC.
    Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.
    Hum Mol Genet 18(17) 3227-43(2009) 19483194