RBRC02796

Information1

Image
BRC No.RBRC02796
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Stab2<tm1>
Former Common nameStab2-KO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development2006年樹立TT2 (ES) → CD1(キメラ) → B6 (backcross 7 世代)
Strain description血中ヒアルロン酸濃度が高い。血液学・生化学・組織学的な異常は見られない。
Colony maintenance繁殖効率:Aホモ同士にて維持可能
ReferencesProc. Natl. Acad. Sci. USA, 109(11):4263-4268 (2012). 22371575

Health Report

Examination Date / Room / Rack2009/07/06Room:2-3Rack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Stab2stabilin 210Stab2targeted mutation 1

Gene symbolGene nameChr.Allele symbolAllele namePromoter
lacZbeta-galactosidase (E. coli)10

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)10

Information2

供与核酸PGK promoter (mouse Phosphoglycerate kinase-1 promoter), E. coli lacZ, E. coli neo, mouse Stab2 genomic DNA
Research applicationFluorescent Proteins/lacZ System
提供条件条件を付加する。利用者は事前に寄託者の提供承諾書を得る。
寄託者の承諾を得る。
Depositor宮島 篤(国立大学法人東京大学)
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
Additional Info.Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

Donner AJ, Wancewicz EV, Murray HM, Greenlee S, Post N, Bell M, Lima WF, Swayze EE, Seth PP.
Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver.
Nucleic Acid Ther 27(4) 209-220(2017) 28448194

Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG.
Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1.
PLoS Genet. (2018) 30372444