RBRC02370

Information1

Image
BRC No.RBRC02370
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Grn<tm1>
Former Common nameProgranulin knock-out mouse
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainC57BL/6
Appearanceblack [a/a B/B C/C]
Strain development開発者/機関:東京大学大学院農学生命科学研究科獣医生理学教室および東京大学医科学研究科ヒト疾患モデル研究センターとの共同研究により作出開発年:2001年
Strain descriptionC57BL/6を背景にprogranulin遺伝子を欠損したマウス
Colony maintenance兄妹交配戻し交配 Background系統名:C57BL/6J(必要に応じて戻し交配も行う)行動の異常がある
ReferencesBehav. Brain Res., 185, 110-118 (2007). 17764761

Health Report

Examination Date / Room / Rack2013/11/25Room:4-ARack:E
2013/09/24Room:4-ARack:E
2013/07/17Room:3-DRack:E
2013/07/16Room:3-DRack:E
2013/06/17Room:3-DRack:E
2013/04/15Room:3-DRack:E
2013/02/18Room:3-DRack:E
2012/12/10Room:3-DRack:E

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Grngranulin11Grn<tm1Mni>targeted mutation1, Masugi Nishihara

Gene symbolGene nameChr.Allele symbolAllele namePromoter
GHGrowth hormone polyA (Bovine)11GH

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)11mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

供与核酸mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, Bovine growth hormone poly A signal, mouse Grn genomic DNA
Research applicationNeurobiology Research
提供条件条件を付加する。利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって寄託者の指定する文献を引用する。Behav. Brain. Res., 185, 110-118 (2007).
寄託者(開発者)の承諾を得る。
Depositor西原 眞杉(国立大学法人東京大学)
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結精子より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
Additional Info.Genotyping protocol -PCR-
Genetic Background

BRC mice in Publications

Noguchi T, Ebina K, Hirao M, Kawase R, Ohama T, Yamashita S, Morimoto T, Koizumi K, Kitaguchi K, Matsuoka H, Kaneshiro S, Yoshikawa H.
Progranulin plays crucial roles in preserving bone mass by inhibiting TNF- -induced osteoclastogenesis and promoting osteoblastic differentiation in mice.
Biochem. Biophys. Res. Commun. (2015) 26297947

Hafler BP, Klein ZA, Jimmy Zhou Z, Strittmatter SM.
Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice.
Brain Res. (2014) 25234724

Kawase R, Ohama T, Matsuyama A, Matsuwaki T, Okada T, Yamashita T, Yuasa-Kawase M, Nakaoka H, Nakatani K, Inagaki M, Tsubakio-Yamamoto K, Masuda D, Nakagawa-Toyama Y, Nishida M, Ohmoto Y, Nishihara M, Komuro I, Yamashita S.
Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice.
Cardiovasc. Res. 100(1) 125-33(2013) 23847387

Hosokawa M, Arai T, Masuda-Suzukake M, Kondo H, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H.
Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice.
J. Neuropathol. Exp. Neurol. 74(2) 158-65(2015) 25575133

Kuse Y, Ohuchi K, Nakamura S, Hara H, Shimazawa M.
Microglia increases the proliferation of retinal precursor cells during postnatal development.
Mol. Vis. 24 536-545.(2018) 30090016

Kuse Y, Tsuruma K, Sugitani S, Izawa H, Ohno Y, Shimazawa M, Hara H.
Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina.
Sci Rep (2016) 27030285