RBRC02330

Information1

Image
BRC No.RBRC02330
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameNOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk>
Former Common nameNODFcγRnull
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [A/A c/c]
Strain development開発者/機関:東北大学加齢医学研究所遺伝子導入開発年:2004年J1 EScellを用いて作出し、C57BL/6Nに4-8世代戻し交配を行い、さらにNODに12世代戻し交配を行った。
Strain descriptionIgG抗体受容体であるFCRを欠損させたNODマウスである (文献参照) 。
Colony maintenance兄妹交配 特記:ホモ×ホモ戻し交配 Background系統名:日本クレアから入手のNOD/shi, jicその他 ホモ×ホモで交配可能
ReferencesJ. Immunol., 179, 764-774 (2007). 17617565
Cell, 76(3):519-29 (1994). 8313472
Nature, 379, 346-349 (1996). 8552190

Health Report

Examination Date / Room / Rack2020/03/09Room:2-検Rack:C
2020/01/06Room:2-検Rack:C
2019/11/11Room:2-検Rack:C
2011/04/18Room:3-ARack:I
2010/12/13Room:3-ARack:I
2010/10/18Room:3-ARack:I
2010/08/23Room:3-ARack:I
2010/06/21Room:3-ARack:I

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide1Fcer1g<tm1Rav>targeted mutation 1, Jeffrey V Ravetch

Gene symbolGene nameChr.Allele symbolAllele namePromoter
Fcgr2bFc receptor, IgG, low affinity IIb1Fcgr2b<tm1Ttk>targeted mutation 1, Toshiyuki Takai

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)1herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)1herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Information2

供与核酸herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Fcer1g genomic DNA, mouse Fcgr2b genomic DNA
Research applicationImmunology and Inflammation Research
提供条件条件を付加する。
研究成果の公表にあたって寄託者の指定する文献を引用する。J. Immunol., 179, 764-774 (2007).
Depositor高井 俊行(国立大学法人東北大学)
Strain Status凍結胚のアイコン凍結胚
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Kayes T, Fang Y, Yu S, Downey E, Wang S, Braley-Mullen H.
Agonistic Anti-CD40 Induces Thyrocyte Proliferation and Promotes Thyroid Autoimmunity by Increasing CD40 Expression on Thyroid Epithelial Cells.
J. Immunol. (2013) 23509363