BRC No.RBRC02095
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.B6D2-Tg(Th-EGFP)21-31Koba
Former Common nameB6.Cg-Tg(TH-GFP)21-31
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain development福島県立医科大学医学部・小林和人先生(1998)。B6D2F2受精卵へインジェクションにより作出。C57BL/6Jに戻し交配された。2ラインあり。RBRC02095(メインライン)、RBRC03162。
Strain descriptionラットチロシン水酸化酵素 (TH) 遺伝子プロモーターに、オワンクラゲ緑色蛍光タンパク質 (GFP) 遺伝子を接続した導入遺伝子を持つ。Tgマウスは脳内および末梢器官のカテコールアミン合成細胞がGFPにより標識される。ホモマウスは致死 (原因は不明) 。
Colony maintenanceCarrier x Noncarrier [C57BL/6JJcl]
ReferencesJ. Neurochem., 82, 295-304 (2002). 12124430

Health Report

Examination Date / Room / Rack2020/07/06Room:4-ARack:K


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
GFPGreen Fluorescent Protein (Jellyfish)UNrat tyrosine hydroxylase (TH) promoter


供与核酸rat tyrosine hydroxylase (TH) promoter, rabbit beta-globin intron, jelly fish green fluorescent protein (GFP) gene, rabbit beta-globin poly A, SV40 early gene poly A
Research applicationFluorescent Proteins/lacZ System
Neurobiology Research
研究成果の公表にあたって寄託者の指定する文献を引用する。J. Neurochem., 82, 295-304 (2002).
Depositor小林 和人(公立大学法人福島県立医科大学)
Strain Status生体のアイコン生体
Strain Availability凍結胚を1ヶ月以内に提供可能
Additional Info.Genotyping protocol -PCR-
GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC's MTA. Please also read Schedule B.
Lab HP (Japanese)
Construct map
Transgene sequence
Mouse of the Month May 2008
Genetic Background

BRC mice in Publications

Masi A,, Narducci R, Resta F, Carbone C, Kobayashi K, Mannaioni G.
Differential contribution of Ih to the integration of excitatory synaptic inputs in Substantia Nigra pars compacta and Ventral Tegmental Area dopaminergic neurons.
Eur. J. Neurosci. (2015) 26354486

Kiyokage E, Kobayashi K, Toida K.
Spatial distribution of synapses on tyrosine hydroxylase expressing juxtaglomerular cells in the mouse olfactory glomerulus.
J. Comp. Neurol. (2016) 27864931

Suzuki Y, Kiyokage E, Sohn J, Hioki H, Toida K.
Structural basis for serotonergic regulation of neural circuits in the mouse olfactory bulb.
J. Comp. Neurol. (2014) 25234191

Sawada M, Kaneko N, Inada H, Wake H, Kato Y, Yanagawa Y, Kobayashi K, Nemoto T, Nabekura J, Sawamoto K.
Sensory Input Regulates Spatial and Subtype-Specific Patterns of Neuronal Turnover in the Adult Olfactory Bulb.
J. Neurosci. 31(32) 11587-11596(2011) 21832189

Zhu S, Zhao C, Wu Y, Yang Q, Shao A, Wang T, Wu J, Yin Y, Li Y, Hou J, Zhang X, Zhou G, Gu X, Wang X, Bustelo XR, Zhou J.
Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking.
Nat. Neurosci. (2015) 26147533