BRC No.RBRC01869
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Nod2<tm1Jhgt>
Former Common nameCard15 KO (C57BL/6N background)
H-2 Haplotype
ES Cell line
Background strain
Strain developmentINSERM・Marco Giovannini。PGK-hygromycinカセットは除去済み。
Strain descriptionCard15 (Nod2) 遺伝子のノックアウトマウス。エクソン1をEGFPカセットで置換。GFPの発現は低い。C57BL/6背景 (RBRC01869) 、C57BL/6と129混合背景 (RBRC01941) 。
Colony maintenanceHomozygote x Homozygote
ReferencesPLoS ONE, 2(6), e523 (2007). 17565376

Health Report

Examination Date / Room / Rack2008/12/08Room:3-3Rack:D


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Nod2caspase recruitment domain family, member 158Nod2

Gene symbolGene nameChr.Allele symbolAllele namePromoter
EGFPEnhanced Green Fluorescent Protein, F64L and S65T (Aequorea victoria)8EGFP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP8loxP


供与核酸jellyfish EGFP cDNA, SV40 polyA, Phage P1 loxP site, mouse Nod2 genomic DNA
Research applicationCre/loxP system
Fluorescent Proteins/lacZ System
Immunology and Inflammation Research
Internal/Organ Research
Mouse Models for Human Disease
RECIPIENT shall keep DEPOSITOR apprised of any results obtained from the BIOLOGICAL RESOURCE in the course of the research, as soon as they are available. Moreover, if the research results in a potential invention or a substance that may have potential commercial value (hereinafter referred as to the "Invention") RECIPIENT will promptly disclose this Invention to DEPOSITOR with samples thereof for DEPOSITOR's internal use.
RECIPIENT and DEPOSITOR will consult together and agree about the possibility of filing one or more patent application to Invention conceived by one or more employees of Recipients that directly arise out of the research. The Parties will negotiate in good faith the conditions of such patent application according to each party's inventiveness contribution in the Invention.
In case of such Invention, patentable or not, reduced in practice or developed in the course of the research that could not have been obtained, reduced to practice or developed but from using the Material and/or Confidential Information, RECIPIENT and DEPOSITOR shall confer with one another as regards licensing and commercialization of such Invention to negotiate in good faith the terms of an institutional agreement as regards said matters.
DepositorMarco Giovannini(INSERM)
Strain Status凍結胚のアイコン凍結胚
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
Additional Info.Genotyping protocol -PCR-
GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC's MTA. Please also read Schedule B.
Mouse of the Month Jun 2007

BRC mice in Publications

Zong J, Salim M, Zhou H, Bian ZY, Dai J, Yuan Y, Deng W, Zhang JY, Zhang R, Wu QQ, Tang QZ.
NOD2 deletion promotes cardiac hypertrophy and fibrosis induced by pressure overload.
Lab. Invest. 93(10) 1128-36(2013) 23958879