Strain Data Sheet

RBRC01106

Strain Information

Image
BRC No.RBRC01106
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameICR.Cg-Sema3a<tm1.2Tyag>/TyagRbrc
Former Common namesemaphorin III/D (conditional) Targeting mice
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainJcl:ICR
Appearancealbino [c/c]
Strain development生理学研究所・谷口 雅彦先生、八木 健先生(1997)。TT2 ES細胞を用いて作出。ICR混合背景。
Strain descriptionSemaphorin III/D (Sema3a) 遺伝子のfloxedマウス。Nullアレル (RBRC01104) 、lacZアレル (RBRC01105) 、floxedアレル (RBRC01106) 。
Colony maintenanceHomozygote x Homozygote [or Crossing to Jcl:ICR]
References
Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection.
Taniguchi M, Yuasa S, Fujisawa H, Naruse I, Saga S, Mishina M, Yagi T
Neuron, 19, 519-530 (1997). 9331345

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A5Sema3atargeted mutation 1.2, Takeshi Yagi
  • hypogonadotropic hypogonadism 16 with or without anosmia(MedGEN)
  • loxPphage P1 loxP5loxP
  • hypogonadotropic hypogonadism 16 with or without anosmia(MedGEN)
  • loxPphage P1 loxP5loxP
  • hypogonadotropic hypogonadism 16 with or without anosmia(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal axon guidance(MP:0002961)
  • Detailed phenotype data

    Ordering Information

    供与核酸phage P1 loxP sites, mouse semaphorin 3A genomic DNA
    Research applicationCre/loxP system
    Neurobiology Research
    提供条件利用者は事前に寄託者の提供承諾書を得る。研究成果の公表にあたって寄託者の指定する文献を引用する。Neuron, 19, 519-530 (1997). 本件リソースの特許権ならびに知的所有権は寄託者が保持しており、利用者が本件リソースから得られた結果により特許等を申請する場合には、事前に寄託者と協議する。利用者は本件リソースを利用して寄託後2年間以内に行った研究結果等を学術論文発表する場合には寄託者との共著の要否について別途協議する。
    Depositor八木 健(岡崎国立共同研究機構)
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-
    Mouse of the Month Aug 2006

    BRC mice in Publications

    Hayashi M, Nakashima T, Yoshimura N, Okamoto K, Tanaka S, Takayanagi H.
    Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging.
    Cell Metab 29(3) 627-637.e5(2019) 30661929
    Fukuda T, Takeda S, Xu R, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H.
    Sema3A regulates bone-mass accrual through sensory innervations.
    Nature 497(7450) 490-3(2013) 23644455
    Zhou J, Wen Y, She L, Sui YN, Liu L, Richards LJ, Poo MM.
    Axon position within the corpus callosum determines contralateral cortical projection.
    Proc Natl Acad Sci U S A 110(29) E2714-23(2013) 23812756
    Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M, Sakano H.
    Pre-target axon sorting establishes the neural map topography.
    Science 325(5940) 585-90(2009) 19589963
    Shadrach JL, Pierchala BA.
    Semaphorin3A Signaling Is Dispensable for Motor Axon Reinnervation of the Adult Neuromuscular Junction.
    eNeuro 5(3) (2018) 29774231