BRC No.RBRC00388
TypeSpontaneous Mutation
SpeciesMus musculus
Strain namePROD-Cacna1a<tg-rol>/NemOdaRbrc
Former Common namePROD-rol/+
H-2 Haplotype
ES Cell line
Background strain
Appearanceagouti with white spot [A/A B/? C/C s/s]
Strain development乳仔死亡の多発を特性とするSIIIとC57BL/6Ngaとを交配し(1967年),1969年,この交配の後代(6世代目)に,歩行異常マウスが出現(名古屋大学農学部).その後,名古屋大学環境医学研究所(織田銑一先生)を経て,理研BRCに導入された。
Strain descriptionrol: Rolling mouse Nagoya 遺伝性運動失調症Cchl1a4<tg>遺伝子座 (第8染色体) におけるミュータント.tg: tottering mouse (小脳性運動失調症) の複対立遺伝子 (tgrol) .劣性単一遺伝子.小脳性失調.生後10‐14日に歩行異常が起こる.特に後肢のアンバランスが著しく,横転を繰り返す.
Colony maintenanceRollingの♀は繁殖可能で交配に使えるが,繁殖能力や哺育能力は正常個体と比べると劣る.Rollingの♂は交尾動作が不調で交配に用いるのは難しい.哺乳期に正常個体と同居させておくとRollingの成育はよくない.
ReferencesNeurosci. Lett., 266, 49-52 (1999). 10336181
Dev. Psycobiology, 19, 67-77 (1986). 3699253
J. Neurosci., 20, 5654-5662 (2000). 10908603
Neurosci. Res., 5, 316-324 (1988). 2897649
実験動物, 22, 281-288 (1973).
チャンネル病, 脳の科学(1999年増刊号), 星和書店, 東京, 101-106 (1999).
実験動物の遺伝的コントロール(富田武,江崎考三郎,早川純一郎,編)ソフトサイエンス社, 東京, pp. 248-259 (1983).
名古屋大学環境医学研究所年報, 27, 195-197 (1976).
医学のあゆみ, 101, 74-75 (1977).
Genetic Approches to Developmental Neurobiology (TSUKADA Yasuzo, ed), University of Tokyo Press, Tokyo, pp. 171-181 (1982).
Jpn. J. Genet., 56, 295-299 (1981).
名古屋大学環境医学研究所年報, 28, 212-213 (1977).
名古屋大学環境医学研究所年報, 27, 193-194 (1976).
名古屋大学環境医学研究所年報, 26, 7-9 (1975).
Biomed. Res., 1, 88-90 (1980).

Health Report

Examination Date / Room / RackNo Data


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit8Cacna1a<tg-rol>rolling Nagoya


Research applicationDevelopmental Biology Research
Genetics Research
Neurobiology Research
Depositor織田 銑一(名古屋大学)
Strain Status凍結胚のアイコン凍結胚
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
Additional Info.

BRC mice in Publications

Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E.
Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction.
Behav. Brain Res. (2013) 24177210

Takahashi E, Niimi K, Itakura C.
Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya.
Behav. Brain Res. 204(1) 241-5(2009) 19467269

Tian X, Zhou Y, Gao L, He G, Jiang W, Li W, Takahashi E.
Analysis of ischemic neuronal injury in Cav2.1 channel alpha 1 subunit mutant mice.
Biochem. Biophys. Res. Commun. (2013) 23545255

Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M.
Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.
Blood 107(3) 1078-84(2006) 16219795

Kim TY, Niimi K, Takahashi E.
Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury.
Brain Res. (2016) 27840189

Takahashi E, Niimi K, Itakura C.
Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice.
Brain Res. 1279 16983 (2009) 19446536

Takahashi E, Niimi K.
Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya.
Exp. Gerontol. 44(4) 274-9(2009) 19073246

Takahashi E, Niimi K, Itakura C.
Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya.
J. Mol. Neurosci. 41(2) 223-9(2010) 19609731

Fukumoto N, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Ca(2+) channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca(2+) channel mutant mouse, rolling mouse Nagoya.
Neurosci. Res. 73(3) 199-206(2012) 22575052

Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya.
Neuroscience 160(1) 165-73(2009) 19248821