Strain Data Sheet

RBRC00213

Strain Information

Image
BRC No.RBRC00213
TypeWild-derived Inbred
SpeciesMus musculus musculus
Strain namePWK
Former Common name
H-2 Haplotype
ES Cell line
Background strainPWK [Mus musculus musculus]
Appearanceagouti [A/A]
Strain developmentチェコのLhotkaにて捕獲された野生個体をもとに育成された系統である。
Strain descriptionPWKは1974年にチェコ共和国のLhotkaにて捕獲されたMus musculus musculus に属する一つがいのマウスに由来する (Von Deimling et al, 1988) 。この系統は米国Roswell Park Cancer研究所 (Buffalo, NY) の故Chapman博士より理研(筑波) に送られたもので、その後30代以上兄妹交配によって維持されている。C57BL/6とPWKのF1、雑種雄は不妊であることが示されている。
Colony maintenance兄妹交配による、繁殖は良好。
References
V beta 17 gene polymorphism in wild-derived mouse strains: two amino acid substitutions in the V beta 17 region greatly alter T cell receptor specificity.
Cazenave P A, Marche P N, Jouvin-Marche E, Voegtle D, Bonhomme F, Bandeira A, Coutinho A
Cell, 63, 717-728 (1990). 2225073

V beta 17 T-cell deletion by endogenous mammary tumor virus in wild-type-derived mouse strain.
Jouvin-Marche E, Cazenave P A, Voegtle D, Marche P N
Proc. Natl. Acad. Sci. USA, 89, 3232-3235 (1992). 1314381

von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene.
Nichols W C, Cooney K A, Mohlke K L, Ballew J D, Yang A, Bruck M E, Reddington M, Novak E K, Swank R T, Ginsburg D
Blood, 83, 3225-3231 (1994). 8193357

Survival of patchwork melanoblasts is dependent upon their number in the hair follicle at the end of embryogenesis.
Aubin-Houzelstein G, Bernex F, Elbaz C, Panthier J J
Dev. Biol., 198, 266-276 (1998). 9659932

Identification of seven loci for static glucokinesis and dynamic glucokinesis in mice.
Komatsu S, Kiyosawa H, Yoshiki A, Okazaki Y, Yoshino M, Tomaru Y, Watanabe S, Muramatsu M, Kusakabe M, Hayashizaki Y
Mamm. Genome, 13, 293-298 (2002). 12115031

Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.
Poirier C, Yoshiki A, Fujiwara K, Guenet J L, Kusakabe M
Genetics, 162, 831-840 (2002). 12399393

Health Report

Examination Date / Room / Rack2024/11/25Room:4-CRack:B囮検査
2024/08/26Room:4-CRack:B囮検査
2024/05/27Room:4-CRack:B囮検査
2024/02/26Room:4-CRack:B囮検査
2023/11/27Room:4-CRack:B囮検査
2023/08/28Room:4-CRack:B囮検査
2023/05/29Room:4-CRack:B囮検査

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal hemostasis(MP:0009676)

  • irregular coat pigmentation(MP:0000372)
  • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationCell Biology Research
    Developmental Biology Research
    Genetics Research
    Reproductive Biology Research
    提供条件条件を付加しない。
    DepositorRoswell Park Cancer Inst.(Roswell Park Cancer Inst.)
    Strain Status生体のアイコン生体
    凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    生体マウスを1~3ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Click Here for Mouse genomic DNA (RIKEN DNA Bank)

    BRC mice in Publications

    Saito A, Tahara R, Hirose M, Kadota M, Hasegawa A, Kondo S, Kato H, Amano T, Yoshiki A, Ogura A, Kiyosawa H.
    Inter-subspecies mouse F1 hybrid embryonic stem cell lines newly established for studies of allelic imbalance in gene expression.
    Exp Anim (2024) 38447983
    Fujiwara K, Inagaki Y, Soma M, Ozaki T, Nagase H.
    Mapping of new skin tumor susceptibility loci by a phenotype-driven congenic approach.
    Oncol Lett 16(5) 6670-6676(2018) 30405807
    Bamunusinghe D, Naghashfar Z, Buckler-White A, Plishka R, Baliji S, Liu Q, Kassner J, Oler AJ, Hartley J, Kozak CA.
    Sequence Diversity, Intersubgroup Relationships, and Origins of the Mouse Leukemia Gammaretroviruses of Laboratory and Wild Mice.
    J Virol 90(8) 4186-98(2016) 26865715
    Morita S, Nakabayashi K, Kawai T, Hayashi K, Horii T, Kimura M, Kamei Y, Ogawa Y, Hata K, Hatada I.
    Gene expression profiling of white adipose tissue reveals paternal transmission of proneness to obesity.
    Sci Rep 6 21693(2016) 26868178
    Mochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi M, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A.
    Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus.
    PLoS One 9(12) e114305(2014) 25470728
    Morita S, Horii T, Kimura M, Arai Y, Kamei Y, Ogawa Y, Hatada I.
    Paternal allele influences high fat diet-induced obesity.
    PLoS One 9(1) e85477(2014) 24416415
    Horii T, Yanagisawa E, Kimura M, Morita S, Hatada I.
    Epigenetic differences between embryonic stem cells generated from blastocysts developed in vitro and in vivo.
    Cell Reprogram 12(5) 551-63(2010) 20818993
    Hayashida K, Kohno S.
    Hybrid male sterility is caused by mitochondrial DNA deletion.
    Mol Biol Rep 36(6) 1365-9(2009) 18649010
    Fujiwara K, Igarashi J, Irahara N, Kimura M, Nagase H.
    New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK.
    BMC Genet 8 39(2007) 17598916
    Yamasaki-Ishizaki Y, Kayashima T, Mapendano CK, Soejima H, Ohta T, Masuzaki H, Kinoshita A, Urano T, Yoshiura K, Matsumoto N, Ishimaru T, Mukai T, Niikawa N, Kishino T.
    Role of DNA methylation and histone H3 lysine 27 methylation in tissue-specific imprinting of mouse Grb10.
    Mol Cell Biol 27(2) 732-42(2007) 17101788
    Yamasaki Y, Kayashima T, Soejima H, Kinoshita A, Yoshiura K, Matsumoto N, Ohta T, Urano T, Masuzaki H, Ishimaru T, Mukai T, Niikawa N, Kishino T.
    Neuron-specific relaxation of Igf2r imprinting is associated with neuron-specific histone modifications and lack of its antisense transcript Air.
    Hum Mol Genet 14(17) 2511-20(2005) 16037066
    Wang Y, Joh K, Masuko S, Yatsuki H, Soejima H, Nabetani A, Beechey CV, Okinami S, Mukai T.
    The mouse Murr1 gene is imprinted in the adult brain, presumably due to transcriptional interference by the antisense-oriented U2af1-rs1 gene.
    Mol Cell Biol 24(1) 270-9(2004) 14673161
    Kayashima T, Yamasaki K, Joh K, Yamada T, Ohta T, Yoshiura K, Matsumoto N, Nakane Y, Mukai T, Niikawa N, Kishino T.
    Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting.
    Genomics 81(6) 644-7(2003) 12782135
    Komatsu S, Kiyosawa H, Yoshiki A, Okazaki Y, Yoshino M, Tomaru Y, Watanabe S, Muramatsu M, Kusakabe M, Hayashizaki Y.
    Identification of seven loci for static glucokinesis and dynamic glucokinesis in mice.
    Mamm Genome 13(6) 293-8(2002) 12115031