Strain Data Sheet

RBRC00209

Information1

Image
BRC No.RBRC00209
TypeWild-derived Inbred
SpeciesMus musculus molossinus
Strain nameMSM/Ms
Former Common nameM.MOL-MSM
H-2 Haplotype
ES Cell line
Background strainMSM [Mus musculus molossinus]
Appearancewhite-bellied agouti [Aw/Aw]
Strain development国立遺伝学研究所より導入。1979年に静岡県三島市にて,森脇和郎博士によって捕獲された野生マウスをもとに育成された。寄託後、現在CV+F3、SPF+20を経る。維持は通常の兄妹交配により行う。通常,同腹仔の場合は離乳と同時に交配を行う。同腹仔以外の場合は雄8-12週齢,雌4-8週齢(交配未経験の場合)で繁殖に供用するとよい。動物の健康管理に心がけ,育成環境の統一を図るために,ケージ収容匹数を一定に保つ。野生由来系統であるため、動きが激しく、素早いため、取り扱いには注意する。とりわけ、ケージ網につかまることが多いため、マウス移動時には注意を必要とする。巣箱を使用すると繁殖性が向上する。繁殖良好。交配成功率90.6%(n=53)、初産日齢77.7±13.3日(±SD)、平均産仔数5.2±1.8仔(±SD、n=102)
Strain descriptionMus musculus molossinusに属する。国立遺伝学研究所より導入。1979年に静岡県三島市にて,森脇和郎博士によって捕獲された野生マウスをもとに育成された近交系マウス。欧米で育成されてきた多くの実験用近交系マウスと比較すると,小型で,マウスが本来持っている俊敏かつ繊細な行動的特徴を有している。ガンや肥満などになりにくい有用な遺伝子を持っていると考えられている。ガン研究,遺伝学研究など幅広く利用されている。
Colony maintenance
ReferencesProc. Natl. Acad. Sci. USA, 94, 10817-10820 (1997). 9380717
Exp. Anim., 58, 123-134 (2009). 19448335
Mamm. Genome, 12, 750-752 (2001). 11641725
Mamm. Genome, 20, 14-20(2009). 19082856
Genome Res., 18, 500-508 (2008). 18256237
Cancer Res., 56, 3716-3720 (1996). 12097280
Genome Res., 14, 2439-2447 (2004). 15574823
Acta Med. Okayama., 50, 319-324(1996). 8985469
Cancer Lett., 111, 97-104 (1997). 9022133
Exp. Anim., 44, 43-48 (1995). 7705478

Health Report

Examination Date / Room / Rack2022/08/29Room:4-CRack:F
2022/05/31Room:4-CRack:F
2022/03/15Room:4-CRack:F
2021/12/13Room:4-CRack:F
2021/09/13Room:4-CRack:F
2021/06/14Room:4-CRack:F
2021/03/29Room:4-CRack:F
2021/01/05Room:4-CRack:F
2020/10/05Room:4-CRack:F

Gene

Gene info

Information2

供与核酸
Research applicationCancer Research
Genetics Research
提供条件条件を付加する。
研究成果の公表にあたって寄託者の指定する文献を引用する。① Exp. Anim., 58, 123-134 (2009). or/and ② Genome Res., 23: 1329–1338 (2013).
研究成果の公表にあたって謝辞の表明を必要とする。
当該リソースを使用した研究成果に基づき特許等の申請を行う場合は、別途協議を行う。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。(連絡先:マウス開発研究室 小出 剛 <tkoide@nig.ac.jp>)
Depositor城石 俊彦(国立遺伝学研究所)
Strain Status生体のアイコン生体
凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
生体マウスを1~3ヶ月以内に提供可能
Additional Info.Click Here for Mouse genomic DNA (RIKEN DNA Bank)
Click Here for BAC clone (RIKEN DNA Bank)
Mouse of the Month Apr 2009
Genetic Background
Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

Kawakami M, Yamamura K.
Cranial bone morphometric study among mouse strains.
BMC Evol Biol 8 73(2008) 18307817

Hasegawa A, Mochida K, Matoba S, Inoue K, Hama D, Kadota M, Hiraiwa N, Yoshiki A, Ogura A.
Development of assisted reproductive technologies for Mus spretus†.
Biol Reprod 104(1) 234-243(2021) 32990726

Hasegawa A, Mochida K, Matoba S, Yonezawa K, Ohta A, Watanabe G, Taya K, Ogura A.
Efficient production of offspring from Japanese wild-derived strains of mice (Mus musculus molossinus) by improved assisted reproductive technologies.
Biol Reprod 86(5) 167, 1-7(2012) 22337332

Ikeda R, Shiura H, Numata K, Sugimoto M, Kondo M, Mise N, Suzuki M, Greally JM, Abe K.
Large, male germ cell-specific hypomethylated DNA domains with unique genomic and epigenomic features on the mouse X chromosome.
DNA Res 20(6) 549-65(2013) 23861320

Omi N, Kiyokawa E, Matsuda M, Kinoshita K, Yamada S, Yamada K, Matsushima Y, Wang Y, Kawai J, Suzuki M, Hayashizaki Y, Hiai H.
Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse.
Exp Eye Res 86(5) 828-34(2008) 18396277

Mise N, Fuchikami T, Sugimoto M, Kobayakawa S, Ike F, Ogawa T, Tada T, Kanaya S, Noce T, Abe K.
Differences and similarities in the developmental status of embryo-derived stem cells and primordial germ cells revealed by global expression profiling.
Genes Cells 13(8) 863-77(2008) 18782224

Oka A, Mita A, Sakurai-Yamatani N, Yamamoto H, Takagi N, Takano-Shimizu T, Toshimori K, Moriwaki K, Shiroishi T.
Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies.
Genetics 166(2) 913-24(2004) 15020476

Kohama C, Kato H, Numata K, Hirose M, Takemasa T, Ogura A, Kiyosawa H.
ES cell differentiation system recapitulates the establishment of imprinted gene expression in a cell-type-specific manner.
Hum Mol Genet 21(6) 1391-401(2012) 22156770

Araki K, Takeda N, Yoshiki A, Obata Y, Nakagata N, Shiroishi T, Moriwaki K, Yamamura K.
Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain.
Mamm Genome 20(1) 14-20(2009) 19082856

Johnsen JM, Levy GG, Westrick RJ, Tucker PK, Ginsburg D.
The endothelial-specific regulatory mutation, Mvwf1, is a common mouse founder allele.
Mamm Genome 19(1) 32-40(2008) 18188647

Nunome M, Ishimori C, Aplin KP, Tsuchiya K, Yonekawa H, Moriwaki K, Suzuki H.
Detection of recombinant haplotypes in wild mice (Mus musculus) provides new insights into the origin of Japanese mice.
Mol Ecol 19(12) 2474-89(2010) 20465587

Shinmen A, Honda A, Ohkawa M, Hirose M, Ogonuki N, Yuzuriha M, Miki H, Mochida K, Inoue K, Abe K, Ito M, Ogura A.
Efficient production of intersubspecific hybrid mice and embryonic stem cells by intracytoplasmic sperm injection.
Mol Reprod Dev 74(9) 1081-8(2007) 17290420

Yagi M, Kabata M, Tanaka A, Ukai T, Ohta S, Nakabayashi K, Shimizu M, Hata K, Meissner A, Yamamoto T, Yamada Y.
Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development.
Nat Commun 11(1) 3199(2020) 32581223

Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Masuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa A, Abe K, Yoshimura T, Nabeshima T, Ebihara S.
Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests.
Nat Genet 41(6) 688-95(2009) 19465912

Yagi M, Kishigami S, Tanaka A, Semi K, Mizutani E, Wakayama S, Wakayama T, Yamamoto T, Yamada Y.
Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation.
Nature 548(7666) 224-227(2017) 28746308

Sugimoto M, Abe K.
X chromosome reactivation initiates in nascent primordial germ cells in mice.
PLoS Genet 3(7) e116(2007) 17676999

Mochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi M, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A.
Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus.
PLoS One 9(12) e114305(2014) 25470728

Hirose M, Hasegawa A, Mochida K, Matoba S, Hatanaka Y, Inoue K, Goto T, Kaneda H, Yamada I, Furuse T, Abe K, Uenoyama Y, Tsukamura H, Wakana S, Honda A, Ogura A.
CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene.
Sci Rep 7 42476(2017) 28195201

Yagi M, Kabata M, Ukai T, Ohta S, Tanaka A, Shimada Y, Sugimoto M, Araki K, Okita K, Woltjen K, Hochedlinger K, Yamamoto T, Yamada Y.
De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency.
Stem Cell Reports 12(5) 1113-1128(2019) 31056481