Strain Information | |
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Image | |
BRC No. | RBRC00209 |
Type | Wild-derived Inbred |
Species | Mus musculus molossinus |
Strain name | MSM/Ms |
Former Common name | M.MOL-MSM |
H-2 Haplotype | |
ES Cell line | |
Background strain | MSM [Mus musculus molossinus] |
Appearance | white-bellied agouti [Aw/Aw] |
Strain development | 国立遺伝学研究所より導入。1979年に静岡県三島市にて,森脇和郎博士によって捕獲された野生マウスをもとに育成された。寄託後、現在CV+F3、SPF+20を経る。維持は通常の兄妹交配により行う。通常,同腹仔の場合は離乳と同時に交配を行う。同腹仔以外の場合は雄8-12週齢,雌4-8週齢(交配未経験の場合)で繁殖に供用するとよい。動物の健康管理に心がけ,育成環境の統一を図るために,ケージ収容匹数を一定に保つ。野生由来系統であるため、動きが激しく、素早いため、取り扱いには注意する。とりわけ、ケージ網につかまることが多いため、マウス移動時には注意を必要とする。巣箱を使用すると繁殖性が向上する。繁殖良好。交配成功率90.6%(n=53)、初産日齢77.7±13.3日(±SD)、平均産仔数5.2±1.8仔(±SD、n=102) |
Strain description | Mus musculus molossinusに属する。国立遺伝学研究所より導入。1979年に静岡県三島市にて,森脇和郎博士によって捕獲された野生マウスをもとに育成された近交系マウス。欧米で育成されてきた多くの実験用近交系マウスと比較すると,小型で,マウスが本来持っている俊敏かつ繊細な行動的特徴を有している。ガンや肥満などになりにくい有用な遺伝子を持っていると考えられている。ガン研究,遺伝学研究など幅広く利用されている。 |
Colony maintenance | |
References | Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes. Masui T, Tezuka N, Nakanishi H, Inada K, Miyashita N, Tatematsu M Cancer Lett., 111, 97-104 (1997). 9022133Novel mutation of topoisomerase I in rendering cells resistant to camptothecin. Chang J Y, Liu J F, Juang S H, Liu T W, Chen L T Cancer Res., 56, 3716-3720 (1996). 12097280Radiation-induced lymphomas in MSM, (BALB/cHeA x MSM) F1 and (BALB/cHeA x STS/A) F1 hybrid mice. Okumoto M, Mori N, Miyashita N, Moriwaki K, Imai S, Haga S, Hiroishi S, Takamori Y, Esaki K Exp. Anim., 44, 43-48 (1995). 7705478Contribution of Asian mouse subspecies Mus musculus molossinus to genomic constitution of strain C57BL/6J, as defined by BAC-end sequence-SNP analysis. Abe K, Noguchi H, Tagawa K, Yuzuriha M, Toyoda A, Kojima T, Ezawa K, Saitou N, Hattori M, Sakaki Y, Moriwaki K, Shiroishi T Genome Res., 14, 2439-2447 (2004). 15574823Unique inbred strain MSM/Ms established from the Japanese wild mouse. Moriwaki K, Miyashita N, Mita A, Gotoh H, Tsuchiya K, Kato H, Mekada K, Noro C, Oota S, Yoshiki A, Obata Y, Yonekawa H, Shiroishi T Exp. Anim., 58, 123-134 (2009). 19448335Microsatellite database for MSM/Ms and JF1/Ms, molossinus-derived inbred strains. Kikkawa Y, Miura I, Takahama S, Wakana S, Yamazaki Y, Moriwaki K, Shiroishi T, Yonekawa H Mamm. Genome, 12, 750-752 (2001). 11641725Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits. Takada T, Mita A, Maeno A, Sakai T, Shitara H, Kikkawa Y, Moriwaki K, Yonekawa H, Shiroishi T Genome Res., 18, 500-508 (2008). 18256237Minisatellite instability in severe combined immunodeficiency mouse cells. Imai H, Nakagama H, Komatsu K, Shiraishi T, Fukuda H, Sugimura T, Nagao M Proc. Natl. Acad. Sci. USA, 94, 10817-10820 (1997). 9380717Immortalization of cells from brains derived from a strain (MSM/MSfB6C3F1) of wild mouse. Yuasa T, Abe E, Oshimura M, Namba M Acta Med. Okayama., 50, 319-324(1996). 8985469The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains. Takada T, Ebata T, Noguchi H, Keane T M, Adams D J, Narita T, Shin-I T, Fujisawa H, Toyoda A, Abe K, Obata Y, Sakaki Y, Moriwaki K, Fujiyama A, Kohara Y, Shiroishi T Genome Res., 23: 1329-1338 (2013). 23604024more 1 referencesEstablishment of germline-competent embryonic stem cell lines from the MSM/Ms strain. Araki K, Takeda N, Yoshiki A, Obata Y, Nakagata N, Shiroishi T, Moriwaki K, Yamamura K Mamm. Genome, 20, 14-20(2009). 19082856 |
Health Report | |
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Examination Date / Room / Rack | 2024/08/26Room:4-CRack:F 2024/05/27Room:4-CRack:F 2024/02/26Room:4-CRack:F 2023/11/27Room:4-CRack:F 2023/08/28Room:4-CRack:F 2023/05/29Room:4-CRack:F 2023/02/27Room:4-CRack:F |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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供与核酸 | |
Research application | Cancer Research Genetics Research |
提供条件 | 研究成果の公表にあたって寄託者の指定する文献を引用する。① Exp. Anim., 58, 123-134 (2009). or/and ② Genome Res., 23: 1329–1338 (2013).研究成果の公表にあたって謝辞の表明を必要とする。当該リソースを使用した研究成果に基づき特許等の申請を行う場合は、別途協議を行う。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。(連絡先:マウス開発研究室 小出 剛 <tkoide@nig.ac.jp>) |
Depositor | 城石 俊彦(国立遺伝学研究所) |
Strain Status | 生体 凍結胚 凍結精子 |
Strain Availability | 凍結精子を1ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 生体マウスを1~3ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Mouse of the Month Apr 2009 Click Here for Mouse genomic DNA (RIKEN DNA Bank) Click Here for BAC clone (RIKEN DNA Bank) |
BRC mice in Publications |
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Kawakami M, Yamamura K. Cranial bone morphometric study among mouse strains. BMC Evol Biol 8 73(2008) 18307817 |
Hasegawa A, Mochida K, Matoba S, Inoue K, Hama D, Kadota M, Hiraiwa N, Yoshiki A, Ogura A. Development of assisted reproductive technologies for Mus spretus†. Biol Reprod 104(1) 234-243(2021) 32990726 |
Hasegawa A, Mochida K, Matoba S, Yonezawa K, Ohta A, Watanabe G, Taya K, Ogura A. Efficient production of offspring from Japanese wild-derived strains of mice (Mus musculus molossinus) by improved assisted reproductive technologies. Biol Reprod 86(5) 167, 1-7(2012) 22337332 |
Ikeda R, Shiura H, Numata K, Sugimoto M, Kondo M, Mise N, Suzuki M, Greally JM, Abe K. Large, male germ cell-specific hypomethylated DNA domains with unique genomic and epigenomic features on the mouse X chromosome. DNA Res 20(6) 549-65(2013) 23861320 |
Saito A, Tahara R, Hirose M, Kadota M, Hasegawa A, Kondo S, Kato H, Amano T, Yoshiki A, Ogura A, Kiyosawa H. Inter-subspecies mouse F1 hybrid embryonic stem cell lines newly established for studies of allelic imbalance in gene expression. Exp Anim (2024) 38447983 |
Omi N, Kiyokawa E, Matsuda M, Kinoshita K, Yamada S, Yamada K, Matsushima Y, Wang Y, Kawai J, Suzuki M, Hayashizaki Y, Hiai H. Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse. Exp Eye Res 86(5) 828-34(2008) 18396277 |
Mise N, Fuchikami T, Sugimoto M, Kobayakawa S, Ike F, Ogawa T, Tada T, Kanaya S, Noce T, Abe K. Differences and similarities in the developmental status of embryo-derived stem cells and primordial germ cells revealed by global expression profiling. Genes Cells 13(8) 863-77(2008) 18782224 |
Oka A, Mita A, Sakurai-Yamatani N, Yamamoto H, Takagi N, Takano-Shimizu T, Toshimori K, Moriwaki K, Shiroishi T. Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies. Genetics 166(2) 913-24(2004) 15020476 |
Kohama C, Kato H, Numata K, Hirose M, Takemasa T, Ogura A, Kiyosawa H. ES cell differentiation system recapitulates the establishment of imprinted gene expression in a cell-type-specific manner. Hum Mol Genet 21(6) 1391-401(2012) 22156770 |
Araki K, Takeda N, Yoshiki A, Obata Y, Nakagata N, Shiroishi T, Moriwaki K, Yamamura K. Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain. Mamm Genome 20(1) 14-20(2009) 19082856 |
Johnsen JM, Levy GG, Westrick RJ, Tucker PK, Ginsburg D. The endothelial-specific regulatory mutation, Mvwf1, is a common mouse founder allele. Mamm Genome 19(1) 32-40(2008) 18188647 |
Nunome M, Ishimori C, Aplin KP, Tsuchiya K, Yonekawa H, Moriwaki K, Suzuki H. Detection of recombinant haplotypes in wild mice (Mus musculus) provides new insights into the origin of Japanese mice. Mol Ecol 19(12) 2474-89(2010) 20465587 |
Shinmen A, Honda A, Ohkawa M, Hirose M, Ogonuki N, Yuzuriha M, Miki H, Mochida K, Inoue K, Abe K, Ito M, Ogura A. Efficient production of intersubspecific hybrid mice and embryonic stem cells by intracytoplasmic sperm injection. Mol Reprod Dev 74(9) 1081-8(2007) 17290420 |
Yagi M, Kabata M, Tanaka A, Ukai T, Ohta S, Nakabayashi K, Shimizu M, Hata K, Meissner A, Yamamoto T, Yamada Y. Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development. Nat Commun 11(1) 3199(2020) 32581223 |
Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Masuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa A, Abe K, Yoshimura T, Nabeshima T, Ebihara S. Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Nat Genet 41(6) 688-95(2009) 19465912 |
Yagi M, Kishigami S, Tanaka A, Semi K, Mizutani E, Wakayama S, Wakayama T, Yamamoto T, Yamada Y. Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation. Nature 548(7666) 224-227(2017) 28746308 |
Sugimoto M, Abe K. X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genet 3(7) e116(2007) 17676999 |
Mochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi M, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A. Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus. PLoS One 9(12) e114305(2014) 25470728 |
Hirose M, Hasegawa A, Mochida K, Matoba S, Hatanaka Y, Inoue K, Goto T, Kaneda H, Yamada I, Furuse T, Abe K, Uenoyama Y, Tsukamura H, Wakana S, Honda A, Ogura A. CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene. Sci Rep 7 42476(2017) 28195201 |
Yagi M, Kabata M, Ukai T, Ohta S, Tanaka A, Shimada Y, Sugimoto M, Araki K, Okita K, Woltjen K, Hochedlinger K, Yamamoto T, Yamada Y. De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency. Stem Cell Reports 12(5) 1113-1128(2019) 31056481 |