RBRC00169

Information1

Image
BRC No.RBRC00169
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tnc<tm1Sia>/Rbrc
Former Common nameC57BL/6N-TgH(Tnc), B6-TN, TNKO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainC57BL/6NJcl
Appearanceblack [a/a, B/B, C/C]
Strain developmentSaga Y et al. (1992)により作成されたテネイシン欠損マウスを元に開発されたテネイシン欠損コンジェニック系統の一つ。
Strain description細胞外基質テネイシンの機能解析のためのテネシイン欠損マウス系統。C57BL/6NJcl系統は代表的な近交系。B6/NはB6/J よりも繁殖性が良好。創傷治癒の機構解析。細胞接着、細胞間相互作用。毛色は黒。
Colony maintenanceTnc(-/-)同士の兄妹交配。繁殖効率はA。実験群作出にはB6/N との交配必要。繁殖効率はB.
ReferencesExp. Mol. Pathol., 72, 186-195 (2002). 12009782
Biochem. Biophys. Res. Commun., 290, 1220-1227 (2002). 11811993
Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999). 10235540
Genes Dev., 6, 1821-1831 (1992). 1383086
Biochem. Biophys. Res. Commun., 221, 151-156 (1996). 8660327
J. Neurosci., 15, 1971-1983 (1995). 7534342
Am. J. Pathol., 152, 1237-1245 (1998). 9588892
Perspect. Dev. Neurobiol., 2, 111-116 (1994). 7530137
J. Invest. Dermatol., 111, 930-935 (1998). 9856798
Biochem. Biophys. Res. Commun., 231, 356-359 (1997). 9070278
Gene, 104, 177-185 (1991). 1717349
Jpn. J. Cancer Res., 93, 968-975 (2002). 12359049
J. Comp. Neurol., 430, 485-500 (2001). 11169482

Health Report

Examination Date / Room / Rack2020/08/24Room:3-CRack:K
2020/08/17Room:3-CRack:K
2020/06/01Room:3-CRack:K
2020/02/17Room:3-CRack:K
2019/12/16Room:3-CRack:K
2019/12/03Room:3-CRack:K
2019/10/21Room:3-CRack:K
2019/08/26Room:3-CRack:K

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Tnctenascin C4Tnc<tm1Sia>targeted mutation 1, Shinichi Aizawa

Gene symbolGene nameChr.Allele symbolAllele namePromoter
lacZbeta-galactosidase (E. coli)4

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)4mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

供与核酸E. coli lacZ, E. coli neo, mouse phosphoglycerate kinase promoter (PGK promoter), mouse tenascin genomic DNA
Research applicationNeurobiology Research
提供条件条件を付加する。
研究成果の公表にあたって寄託者の指定する文献を引用する。Am. J. Pathol., 152, 1237-1245 (1998). J. Invest. Dermatol., 111, 930-935 (1998). Invest. Ophthalmol. Visual. Sci., 1071-1080 (1999).
DepositorRIKEN BRC(独立行政法人理化学研究所)
Strain Status生体のアイコン生体
凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
生体マウスを1ヶ月以内に提供可能
Additional Info.Genotyping protocol -PCR-
Genetic Background

BRC mice in Publications

Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasawa T, Suda T, Kubota Y.
Extracellular matrix protein Tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration.
Blood (2012) 22553313

Kyoko IMANAKA-YOSHIDA, Kenn-ichi MATSUMOTO, Mari HARA, Teruyo SAKAKURA, Toshimichi YOSHIDA
The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse.
Differentiation 71 291-298(2003) 12823230

Matsumoto K, Takahashi K, Yoshiki A, Kusakabe M, Ariga H.
Invasion of melanoma in double knockout mice lacking tenascin-X and tenascin-C.
Jpn. J. Cancer Res. 93 968-975(2002) 12359049

Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T.
Integrin alpha 9 on lymphatic endothelial cells regulates lymphocyte egress.
Proc. Natl. Acad. Sci. U.S.A. 111(8) 429647(2014) 24516133