Strain Data Sheet

RBRC12193

Strain Information

Image
BRC No.RBRC12193
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Mpo<tm1Mae>
Former Common nameMPO
H-2 Haplotype
ES Cell lineBK4 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase.
Y Aratani, H Koyama, S Nyui, K Suzuki, F Kura, N Maeda
Infect. Immun., 67 (4) 1828-36 (1999). 10085024

Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase.
Y Aratani, F Kura, H Watanabe, H Akagawa, Y Takano, K Suzuki, N Maeda, H Koyama
J. Infect. Dis. 182, 1276-1279 (2000). 10979934

Severe neutrophil-mediated lung inflammation in myeloperoxidase-deficient mice exposed to zymosan.
Kazuhiro Takeuchi, Yu Umeki, Noriko Matsumoto, Kei Yamamoto, Mina Yoshida, Kazuo Suzuki, Yasuaki Aratani
Inflamm. Res., 61, 197-205 (2012). 22116298

Health Report

Examination Date / Room / Rack2026-01-13Room:3-2Rack:DSentinel mouse program
2025-11-04Room:3-2Rack:DSentinel mouse program
2025-08-18Room:3-2Rack:DSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mpo
MGI:97137		myeloperoxidase11Mpo<tm1Mae>
MGI:2176344		targeted mutation 1, Nobuyo Maeda
  • Alzheimer disease type 1(MedGEN)

  • myeloperoxidase deficiency(DisGeNET, MedGEN)
    • neo neomycin resistance gene (E. coli)11 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal metabolism (MP:0005266)

  • abnormal neutrophil physiology (MP:0002463)

  • increased susceptibility to fungal infection (MP:0005399)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E.coli neomycin resistance gene, mouse Mpo genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Infect. Immun. 67: 1828-1836 (1999).The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorYasuaki Aratani (Yokohama City University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data